Zero tolerance! A perspective on monogenic disorders with defective regulatory T cells and IBD-like disease

Ussama M. Abdel-Motal, Ahmad Al-Shaibi, Mamoun Elawad, Bernice Lo

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Recently, several studies have investigated a number of rare monogenic autoimmune disorders, in which the causative genetic defects were identified and found to affect the development or function of regulatory T cells (Tregs). The studies of these disorders have facilitated a deeper understanding of the mechanisms involved in immune regulation and tolerance. Furthermore, these studies have highlighted the importance of Tregs in maintaining homeostasis at the mucosal interface between the host and microbiome. Here, we offer our perspective on these monogenic autoimmune disorders, highlighting their overlapping clinical features with inflammatory bowel disease.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalImmunological Reviews
Volume287
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Immune Tolerance
Microbiota
Regulatory T-Lymphocytes
Inflammatory Bowel Diseases
Homeostasis

Keywords

  • CHAI
  • IBD
  • IL-10
  • IPEX
  • LATAIE
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Zero tolerance! A perspective on monogenic disorders with defective regulatory T cells and IBD-like disease. / Abdel-Motal, Ussama M.; Al-Shaibi, Ahmad; Elawad, Mamoun; Lo, Bernice.

In: Immunological Reviews, Vol. 287, No. 1, 01.01.2019, p. 236-240.

Research output: Contribution to journalReview article

@article{afd1d16345c24cfb838083119655aa65,
title = "Zero tolerance! A perspective on monogenic disorders with defective regulatory T cells and IBD-like disease",
abstract = "Recently, several studies have investigated a number of rare monogenic autoimmune disorders, in which the causative genetic defects were identified and found to affect the development or function of regulatory T cells (Tregs). The studies of these disorders have facilitated a deeper understanding of the mechanisms involved in immune regulation and tolerance. Furthermore, these studies have highlighted the importance of Tregs in maintaining homeostasis at the mucosal interface between the host and microbiome. Here, we offer our perspective on these monogenic autoimmune disorders, highlighting their overlapping clinical features with inflammatory bowel disease.",
keywords = "CHAI, IBD, IL-10, IPEX, LATAIE, Treg",
author = "Abdel-Motal, {Ussama M.} and Ahmad Al-Shaibi and Mamoun Elawad and Bernice Lo",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/imr.12717",
language = "English",
volume = "287",
pages = "236--240",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Zero tolerance! A perspective on monogenic disorders with defective regulatory T cells and IBD-like disease

AU - Abdel-Motal, Ussama M.

AU - Al-Shaibi, Ahmad

AU - Elawad, Mamoun

AU - Lo, Bernice

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Recently, several studies have investigated a number of rare monogenic autoimmune disorders, in which the causative genetic defects were identified and found to affect the development or function of regulatory T cells (Tregs). The studies of these disorders have facilitated a deeper understanding of the mechanisms involved in immune regulation and tolerance. Furthermore, these studies have highlighted the importance of Tregs in maintaining homeostasis at the mucosal interface between the host and microbiome. Here, we offer our perspective on these monogenic autoimmune disorders, highlighting their overlapping clinical features with inflammatory bowel disease.

AB - Recently, several studies have investigated a number of rare monogenic autoimmune disorders, in which the causative genetic defects were identified and found to affect the development or function of regulatory T cells (Tregs). The studies of these disorders have facilitated a deeper understanding of the mechanisms involved in immune regulation and tolerance. Furthermore, these studies have highlighted the importance of Tregs in maintaining homeostasis at the mucosal interface between the host and microbiome. Here, we offer our perspective on these monogenic autoimmune disorders, highlighting their overlapping clinical features with inflammatory bowel disease.

KW - CHAI

KW - IBD

KW - IL-10

KW - IPEX

KW - LATAIE

KW - Treg

UR - http://www.scopus.com/inward/record.url?scp=85058677751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058677751&partnerID=8YFLogxK

U2 - 10.1111/imr.12717

DO - 10.1111/imr.12717

M3 - Review article

C2 - 30565246

AN - SCOPUS:85058677751

VL - 287

SP - 236

EP - 240

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -