Yield of QuantiFERON-TB gold in tube assay and tuberculin skin test in healthy persons from a tuberculosis endemic population

Basirudeen S. Kabeer, Venkatesan Perumal, Paulkumaran Paramasivam, Alamelu Raja

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7 Citations (Scopus)

Abstract

We assessed the yield of the QuantiFERON-TB Gold in tube test (QFT-GIT) and the tuberculin skin test (TST) in healthy persons from our general population, where tuberculosis is endemic and Bacillus Calmette-Guérin is mandatory. The yield of QFT-GIT (2% and TST (1% were very low among children, where the test was positive in 42% and 24% of adults, respectively. Our study results show that QFT-GIT and TST are not influenced by prior Bacillus Calmette- Guérin vaccination. Applying the reduced cut-off point of 0.13 IU/mL is adequate in a pediatric population. Moreover, both the TST and the QFT-GIT demonstrated a low yield in the pediatric population, which suggests that either TST or QFT-GIT alone or in combination can be used to diagnose Mycobacterium tuberculosis infection in our setting.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalJournal of Pediatric Infectious Diseases
Volume5
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

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Keywords

  • diagnosis
  • endemic population
  • healthy children
  • QuantiFERON-TB Gold in tube
  • Tuberculosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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