Workshop on cancer biometrics: Identifying biomarkers and surrogates of cancer in patients - A meeting held at the masur auditorium, national institutes of health

Michael T. Lotze, Ena Wang, Francesco M. Marincola, Nabil Hanna, Peter J. Bugelski, Christine A. Burns, George Coukos, Nitin Damle, Tony E. Godfrey, W. Martin Howell, Monica C. Panelli, Michael A. Perricone, Emanuel F. Petricoin, Guido Sauter, Carmen Scheibenbogen, Steven C. Shivers, D. Lansing Taylor, John N. Weinstein, Theresa L. Whiteside

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The current excitement about molecular targeted therapies has driven much of the recent dialog in cancer diagnosis and treatment. Particularly in the biologic therapy of cancer, identifiable antigenic T-cell targets restricted by MHC molecules and the related novel stress molecules such as MICA/B and Letal allow a degree of precision previously unknown in cancer therapy. We have previously held workshops on immunologic monitoring and angiogenesis monitoring. This workshop was designed to discuss the state of the art in identification of biomarkers and surrogates of tumor in patients with cancer, with particular emphasis on assays within the blood and tumor. We distinguish this from immunologic monitoring in the sense that it is primarily a measure of the tumor burden as opposed to the immune response to it. Recommendations for intensive investigation and targeted funding to enable such strategies were developed in seven areas: genomic analysis; detection of molecular markers in peripheral blood and lymph node by tumor capture and RT-PCR; serum, plasma, and tumor proteomics; immune polymorphisms; high content screening using flow and imaging cytometry; immunohistochemistry and tissue microarrays; and assessment of immune infiltrate and necrosis in tumors. Concrete recommendations for current application and enabling further development in cancer biometrics are summarized. This will allow a more informed, rapid, and accurate assessment of novel cancer therapies.

Original languageEnglish
Pages (from-to)79-119
Number of pages41
JournalJournal of Immunotherapy
Volume28
Issue number2
DOIs
Publication statusPublished - 1 Jan 2005

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Keywords

  • Biologic therapy
  • Biomarkers
  • Cancer
  • Cytokines
  • Genetic polymorphism
  • Genomics
  • High-content screen
  • Immune infiltration
  • Immune response
  • Immune therapy
  • Immunohistochemistry
  • Microarrays
  • Proteomics
  • Surrogates
  • Transcription analysis
  • Tumor necrosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

Cite this

Lotze, M. T., Wang, E., Marincola, F. M., Hanna, N., Bugelski, P. J., Burns, C. A., Coukos, G., Damle, N., Godfrey, T. E., Howell, W. M., Panelli, M. C., Perricone, M. A., Petricoin, E. F., Sauter, G., Scheibenbogen, C., Shivers, S. C., Taylor, D. L., Weinstein, J. N., & Whiteside, T. L. (2005). Workshop on cancer biometrics: Identifying biomarkers and surrogates of cancer in patients - A meeting held at the masur auditorium, national institutes of health. Journal of Immunotherapy, 28(2), 79-119. https://doi.org/10.1097/01.cji.0000154251.20125.2e