Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management

Pavol Zubor, Peter Kubatka, Karol Kajo, Zuzana Dankova, Hubert Polacek, Tibor Bielik, Erik Kudela, Marek Samec, Alena Liskova, Dominika Vlcakova, Tatiana Kulkovska, Igor Stastny, Veronika Holubekova, Jan Bujnak, Zuzana Laucekova, Dietrich Busselberg, Mariusz Adamek, Walther Kuhn, Jan Danko, Olga Golubnitschaja

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

In the global context, the epidemic of breast cancer (BC) is evident for the early 21st century. Evidence shows that national mammography screening programs have sufficiently reduced BC related mortality. Therefore, the great utility of the mammography-based screening is not an issue. However, both false positive and false negative BC diagnosis, excessive biopsies, and irradiation linked to mammography application, as well as sub-optimal mammography-based screening, such as in the case of high-dense breast tissue in young females, altogether increase awareness among the experts regarding the limitations of mammography-based screening. Severe concerns regarding the mammography as the "golden standard" approach demanding complementary tools to cover the evident deficits led the authors to present innovative strategies, which would sufficiently improve the quality of the BC management and services to the patient. Contextually, this article provides insights into mammography deficits and current clinical data demonstrating the great potential of non-invasive diagnostic tools utilizing circulating miRNA profiles as an adjunct to conventional mammography for the population screening and personalization of BC management.

Original languageEnglish
JournalInternational journal of molecular sciences
Volume20
Issue number12
DOIs
Publication statusPublished - 13 Jun 2019

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Keywords

  • breast cancer
  • individualized patient profile
  • liquid biopsy
  • mammography
  • miRNA
  • multi-level diagnostics
  • omics
  • personalized medicine
  • predictive and preventive approach
  • screening

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Zubor, P., Kubatka, P., Kajo, K., Dankova, Z., Polacek, H., Bielik, T., Kudela, E., Samec, M., Liskova, A., Vlcakova, D., Kulkovska, T., Stastny, I., Holubekova, V., Bujnak, J., Laucekova, Z., Busselberg, D., Adamek, M., Kuhn, W., Danko, J., & Golubnitschaja, O. (2019). Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management. International journal of molecular sciences, 20(12). https://doi.org/10.3390/ijms20122878