Which way for drug-mediated immunosuppression?

Vijay K. Sharma, Baogui Li, Ashwani Khanna, Prabodh K. Sehajpal, Manikkam Suthanthiran

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31 Citations (Scopus)

Abstract

The basic immunosuppressive protocol involves the use of multiple drugs, each directed at a discrete site in the T-cell activation cascade. The prevailing paradigm regarding the mechanisms of action of immunosuppressants is that they function to prevent allograft rejection by preventing cell activation, proliferation and/or cytokine production. A new hypothesis is that some of the immunosuppressants might function by stimulating the expression of immunosuppressive molecules and/or cells.

Original languageEnglish
Pages (from-to)784-790
Number of pages7
JournalCurrent Opinion in Immunology
Volume6
Issue number5
DOIs
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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