What do linker histones do in chromatin?

Alan P. Wolffe, Saadi Khochbin, Stefan Dimitrov

Research output: Contribution to journalReview article

120 Citations (Scopus)

Abstract

Knockout experiments in Tetrahymena show that linker histone H1 is not essential for nuclear assembly or cell viability. These results, together with a series of biochemical and cell biological observations, challenge the existing paradigm that requires linker histones to be a key organizing component of higher-order chromatin structure. The H1 knockouts also reveal a much more subtle role for H1. Instead of acting as a general transcriptional repressor, H1 is found to regulate a limited number of specific genes. Surprisingly, H1 can both activate and repress transcription. We discuss how this architectural protein might accomplish this important regulatory role.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalBioEssays
Volume19
Issue number3
Publication statusPublished - Mar 1997
Externally publishedYes

Fingerprint

Histones
Chromatin
Tetrahymena
Transcription
Cell Survival
Genes
Cells
Proteins
Experiments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wolffe, A. P., Khochbin, S., & Dimitrov, S. (1997). What do linker histones do in chromatin? BioEssays, 19(3), 249-255.

What do linker histones do in chromatin? / Wolffe, Alan P.; Khochbin, Saadi; Dimitrov, Stefan.

In: BioEssays, Vol. 19, No. 3, 03.1997, p. 249-255.

Research output: Contribution to journalReview article

Wolffe, AP, Khochbin, S & Dimitrov, S 1997, 'What do linker histones do in chromatin?', BioEssays, vol. 19, no. 3, pp. 249-255.
Wolffe AP, Khochbin S, Dimitrov S. What do linker histones do in chromatin? BioEssays. 1997 Mar;19(3):249-255.
Wolffe, Alan P. ; Khochbin, Saadi ; Dimitrov, Stefan. / What do linker histones do in chromatin?. In: BioEssays. 1997 ; Vol. 19, No. 3. pp. 249-255.
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