Wet-chemical approach for the cell-adhesive modification of polytetrafluoroethylene

Matthias Gabriel, Manfred Dahm, Christian F. Vahl

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20 Citations (Scopus)


Polytetrafluoroethylene (PTFE), a frequently utilized polymer for the fabrication of synthetic vascular grafts, was surface-modified by means of a wet-chemical process. The inherently non-cell-adhesive polymer does not support cellular attachment, a prerequisite for the endothelialization of luminal surface grafts in small diameter applications. To impart the material with cell-adhesive properties a treatment with sodium-naphthalene provided a basis for the subsequent immobilization of the adhesion promoting RGD-peptide using a hydroxy- and amine-reactive crosslinker. Successful conjugation was shown with cell culture experiments which demonstrated excellent endothelial cell growth on the modified surfaces.

Original languageEnglish
Article number035007
JournalBiomedical Materials
Issue number3
Publication statusPublished - 2011
Externally publishedYes


ASJC Scopus subject areas

  • Mechanics of Materials
  • Chemistry (miscellaneous)
  • Biochemistry
  • Medicine(all)

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