Wet-chemical approach for the cell-adhesive modification of polytetrafluoroethylene

Matthias Gabriel, Manfred Dahm, Christian F. Vahl

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Polytetrafluoroethylene (PTFE), a frequently utilized polymer for the fabrication of synthetic vascular grafts, was surface-modified by means of a wet-chemical process. The inherently non-cell-adhesive polymer does not support cellular attachment, a prerequisite for the endothelialization of luminal surface grafts in small diameter applications. To impart the material with cell-adhesive properties a treatment with sodium-naphthalene provided a basis for the subsequent immobilization of the adhesion promoting RGD-peptide using a hydroxy- and amine-reactive crosslinker. Successful conjugation was shown with cell culture experiments which demonstrated excellent endothelial cell growth on the modified surfaces.

Original languageEnglish
Article number035007
JournalBiomedical Materials
Volume6
Issue number3
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Polytetrafluoroethylene
Polytetrafluoroethylenes
Adhesives
Polymers
Chemical Phenomena
Transplants
Grafts
Immobilization
Amines
Blood Vessels
Endothelial Cells
Cell Culture Techniques
Sodium
Endothelial cells
Cell growth
Naphthalene
Cell culture
Peptides
Adhesion
Growth

ASJC Scopus subject areas

  • Mechanics of Materials
  • Chemistry (miscellaneous)
  • Biochemistry
  • Medicine(all)

Cite this

Wet-chemical approach for the cell-adhesive modification of polytetrafluoroethylene. / Gabriel, Matthias; Dahm, Manfred; Vahl, Christian F.

In: Biomedical Materials, Vol. 6, No. 3, 035007, 2011.

Research output: Contribution to journalArticle

Gabriel, Matthias ; Dahm, Manfred ; Vahl, Christian F. / Wet-chemical approach for the cell-adhesive modification of polytetrafluoroethylene. In: Biomedical Materials. 2011 ; Vol. 6, No. 3.
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