Vitamin D for the treatment of painful diabetic neuropathy

Abdul Basit, Khalid Abdul Basit, Asher Fawwad, Fariha Shaheen, Nimra Fatima, Ioannis N. Petropoulos, Uazman Alam, Rayaz Malik

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Abstract

Objective: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy. Methods: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks. Results: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001). Conclusions: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

Original languageEnglish
Article numbere000148
JournalBMJ Open Diabetes Research and Care
Volume4
Issue number1
DOIs
Publication statusPublished - 2 Jan 2016

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Basit, A., Basit, K. A., Fawwad, A., Shaheen, F., Fatima, N., Petropoulos, I. N., Alam, U., & Malik, R. (2016). Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Research and Care, 4(1), [e000148]. https://doi.org/10.1136/bmjdrc-2015-000148