Vitamin D for the treatment of painful diabetic neuropathy

Abdul Basit, Khalid Abdul Basit, Asher Fawwad, Fariha Shaheen, Nimra Fatima, Ioannis N. Petropoulos, Uazman Alam, Rayaz Malik

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy. Methods: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks. Results: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001). Conclusions: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

Original languageEnglish
Article numbere000148
JournalBMJ Open Diabetes Research and Care
Volume4
Issue number1
DOIs
Publication statusPublished - 2 Jan 2016

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Diabetic Neuropathies
Vitamin D
Pain Measurement
Pain
Vitamin D Deficiency
Neuralgia
Therapeutics
Type 2 Diabetes Mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Basit, A., Basit, K. A., Fawwad, A., Shaheen, F., Fatima, N., Petropoulos, I. N., ... Malik, R. (2016). Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Research and Care, 4(1), [e000148]. https://doi.org/10.1136/bmjdrc-2015-000148

Vitamin D for the treatment of painful diabetic neuropathy. / Basit, Abdul; Basit, Khalid Abdul; Fawwad, Asher; Shaheen, Fariha; Fatima, Nimra; Petropoulos, Ioannis N.; Alam, Uazman; Malik, Rayaz.

In: BMJ Open Diabetes Research and Care, Vol. 4, No. 1, e000148, 02.01.2016.

Research output: Contribution to journalArticle

Basit, A, Basit, KA, Fawwad, A, Shaheen, F, Fatima, N, Petropoulos, IN, Alam, U & Malik, R 2016, 'Vitamin D for the treatment of painful diabetic neuropathy', BMJ Open Diabetes Research and Care, vol. 4, no. 1, e000148. https://doi.org/10.1136/bmjdrc-2015-000148
Basit A, Basit KA, Fawwad A, Shaheen F, Fatima N, Petropoulos IN et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Research and Care. 2016 Jan 2;4(1). e000148. https://doi.org/10.1136/bmjdrc-2015-000148
Basit, Abdul ; Basit, Khalid Abdul ; Fawwad, Asher ; Shaheen, Fariha ; Fatima, Nimra ; Petropoulos, Ioannis N. ; Alam, Uazman ; Malik, Rayaz. / Vitamin D for the treatment of painful diabetic neuropathy. In: BMJ Open Diabetes Research and Care. 2016 ; Vol. 4, No. 1.
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