Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production

Sinnie Sin Man Ng, Tsung Hsien Chang, Prafullakumar Tailor, Keiko Ozato, Tomoshige Kino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.

Original languageEnglish
Pages (from-to)1331-1337
Number of pages7
JournalFEBS Letters
Volume585
Issue number9
DOIs
Publication statusPublished - 6 May 2011
Externally publishedYes

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Keywords

  • Coregulator
  • Dendritic cell
  • Histone deacetylase
  • Neuron-derived orphan receptor-1
  • Nuclear receptor
  • Viral infection

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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