Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation

Andrea Lisco, Jean-Charles B. Grivel, Angélique Biancotto, Christophe Vanpouille, Francesco Origgi, Mauro S. Malnati, Dominique Schols, Paolo Lusso, Leonid B. Margolis

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) infection is often accompanied by infection with other pathogens that affect the clinical course of HIV disease. Here, we identified another virus, human herpesvirus 7 (HHV-7) that interferes with HIV type 1 (HIV-1) replication in human lymphoid tissue, where critical events of HIV disease occur. Like the closely related HHV-6, HHV-7 suppresses the replication of CCR5-tropic (R5) HIV-1 in coinfected blocks of human lymphoid tissue. Unlike HHV-6, which affects HIV-1 by upregulating RANTES, HHV-7 did not upregulate any CCR5-binding chemokine. Rather, the inhibition of R5 HIV-1 by HHV-7 was associated with a marked downregulation of CD4, the cellular receptor shared by HHV-7 and HIV-1. HHV-7-induced CD4 downregulation was sufficient for HIV-1 inhibition, since comparable downregulation of CD4 with cyclotriazadisulfonamide, a synthetic macrocycle that specifically modulates expression of CD4, resulted in the suppression of HIV infection similar to that seen in HHV-7-infected tissues. In contrast to R5 HIV-1, CXCR4-tropic (X4) HIV-1 was only minimally suppressed by HHV-7 coinfection. This selectivity in suppression of R5 and X4 HIV-1 is explained by a suppression of HHV-7 replication in X4- but not in R5-coinfected tissues. These results suggest that HIV-1 and HHV-7 may interfere in lymphoid tissue in vivo, thus potentially affecting the progression of HIV-1 disease. Knowledge of the mechanisms of interaction of HIV-1 with HHV-7, as well as with other pathogens that modulate HIV-1 replication, may provide new insights into HIV pathogenesis and lead to the development of new anti-HIV therapeutic strategies.

Original languageEnglish
Pages (from-to)708-717
Number of pages10
JournalJournal of Virology
Volume81
Issue number2
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

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Human Herpesvirus 7
Lymphoid Tissue
HIV-1
Virus Diseases
HIV
Human Herpesvirus 6
Down-Regulation
Virus Replication
Chemokine CCL5
CD4 Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Viral interactions in human lymphoid tissue : Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation. / Lisco, Andrea; Grivel, Jean-Charles B.; Biancotto, Angélique; Vanpouille, Christophe; Origgi, Francesco; Malnati, Mauro S.; Schols, Dominique; Lusso, Paolo; Margolis, Leonid B.

In: Journal of Virology, Vol. 81, No. 2, 01.2007, p. 708-717.

Research output: Contribution to journalArticle

Lisco, Andrea ; Grivel, Jean-Charles B. ; Biancotto, Angélique ; Vanpouille, Christophe ; Origgi, Francesco ; Malnati, Mauro S. ; Schols, Dominique ; Lusso, Paolo ; Margolis, Leonid B. / Viral interactions in human lymphoid tissue : Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation. In: Journal of Virology. 2007 ; Vol. 81, No. 2. pp. 708-717.
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