Vascular factors and multiple measures of early brain health

CARDIA brain MRI study

Lenore J. Launer, Cora E. Lewis, Pamela J. Schreiner, Steve Sidney, Harsha Battapady, David R. Jacobs, Kelvin O. Lim, Mark D'Esposito, Qian Zhang, Jared Reis, Christos Davatzikos, R. Nick Bryan

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: To identify early changes in brain structure and function that are associated with cardiovascular risk factors (CVRF). Design: Cross-sectional brain Magnetic Resonance I (MRI) study. Setting: Community based cohort in three U.S. sites. Participants: A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study. Primary and Secondary Outcomes: 3T brain MR images processed for quantitative estimates of: total brain (TBV) and abnormal white matter (AWM) volume; white matter fractional anisotropy (WM-FA); and gray matter cerebral blood flow (GM-CBF). Total intracranial volume is TBV plus cerebral spinal fluid (TICV). A Global Cognitive Function (GCF) score was derived from tests of speed, memory and executive function. Results: Adjusting for TICV and demographic factors, current smoking was significantly associated with lower GM-CBF and TBV, and more AWM (all <0.05); SA with lower GM-CBF, WM-FA and TBV (p=0.01); increasing BMI with decreasing GM-CBF (p<0003); hypertension with lower GM-CBF, WM-FA, and TBV and higher AWM (all <0.05); and diabetes with lower TBV (p=0.007). The GCS was lower as TBV decreased, AWM increased, and WM-FA (all p<0.01). Conclusion: In middle age adults, CVRF are associated with brain health, reflected in MRI measures of structure and perfusion, and cognitive functioning. These findings suggest markers of midlife cardiovascular and brain health should be considered as indication for early intervention and future risk of late-life cerebrovascular disease and dementia.

Original languageEnglish
Article numbere0122138
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - 26 Mar 2015
Externally publishedYes

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Magnetic resonance
Cerebrovascular Circulation
blood vessels
Brain
Magnetic Resonance Spectroscopy
blood flow
Health
Blood
brain
Anisotropy
risk factors
cerebrovascular disorders
dementia
coronary vessels
African Americans
Medical problems
young adults
Cerebrovascular Disorders
cognition
hypertension

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Launer, L. J., Lewis, C. E., Schreiner, P. J., Sidney, S., Battapady, H., Jacobs, D. R., ... Bryan, R. N. (2015). Vascular factors and multiple measures of early brain health: CARDIA brain MRI study. PLoS One, 10(3), [e0122138]. https://doi.org/10.1371/journal.pone.0122138

Vascular factors and multiple measures of early brain health : CARDIA brain MRI study. / Launer, Lenore J.; Lewis, Cora E.; Schreiner, Pamela J.; Sidney, Steve; Battapady, Harsha; Jacobs, David R.; Lim, Kelvin O.; D'Esposito, Mark; Zhang, Qian; Reis, Jared; Davatzikos, Christos; Bryan, R. Nick.

In: PLoS One, Vol. 10, No. 3, e0122138, 26.03.2015.

Research output: Contribution to journalArticle

Launer, LJ, Lewis, CE, Schreiner, PJ, Sidney, S, Battapady, H, Jacobs, DR, Lim, KO, D'Esposito, M, Zhang, Q, Reis, J, Davatzikos, C & Bryan, RN 2015, 'Vascular factors and multiple measures of early brain health: CARDIA brain MRI study', PLoS One, vol. 10, no. 3, e0122138. https://doi.org/10.1371/journal.pone.0122138
Launer LJ, Lewis CE, Schreiner PJ, Sidney S, Battapady H, Jacobs DR et al. Vascular factors and multiple measures of early brain health: CARDIA brain MRI study. PLoS One. 2015 Mar 26;10(3). e0122138. https://doi.org/10.1371/journal.pone.0122138
Launer, Lenore J. ; Lewis, Cora E. ; Schreiner, Pamela J. ; Sidney, Steve ; Battapady, Harsha ; Jacobs, David R. ; Lim, Kelvin O. ; D'Esposito, Mark ; Zhang, Qian ; Reis, Jared ; Davatzikos, Christos ; Bryan, R. Nick. / Vascular factors and multiple measures of early brain health : CARDIA brain MRI study. In: PLoS One. 2015 ; Vol. 10, No. 3.
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