Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder

M. A. Fullana, P. Alonso, M. Gratacòs, N. Jaurrieta, S. Jiménez-Murcia, C. Segalàs, E. Real, Xavier P. Estivill, J. M. Menchón

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD). Methods: One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed. Results: Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (. P=. 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (. P<. 0.0001) and a lower obsessions severity decrease from pre- to posttreatment (. P=. 0.046). Conclusion: Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalEuropean Psychiatry
Volume27
Issue number5
DOIs
Publication statusPublished - Jul 2012
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Brain-Derived Neurotrophic Factor
Cognitive Therapy
Alleles
Learning
Obsessive Behavior
Therapeutics
Genotype
Pharmacology
Research

Keywords

  • BDNF
  • Cognitive-behavior therapy
  • Extinction
  • Genetics
  • Obsessive-compulsive disorder
  • Val66Met

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Fullana, M. A., Alonso, P., Gratacòs, M., Jaurrieta, N., Jiménez-Murcia, S., Segalàs, C., ... Menchón, J. M. (2012). Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder. European Psychiatry, 27(5), 386-390. https://doi.org/10.1016/j.eurpsy.2011.09.005

Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder. / Fullana, M. A.; Alonso, P.; Gratacòs, M.; Jaurrieta, N.; Jiménez-Murcia, S.; Segalàs, C.; Real, E.; Estivill, Xavier P.; Menchón, J. M.

In: European Psychiatry, Vol. 27, No. 5, 07.2012, p. 386-390.

Research output: Contribution to journalArticle

Fullana, MA, Alonso, P, Gratacòs, M, Jaurrieta, N, Jiménez-Murcia, S, Segalàs, C, Real, E, Estivill, XP & Menchón, JM 2012, 'Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder', European Psychiatry, vol. 27, no. 5, pp. 386-390. https://doi.org/10.1016/j.eurpsy.2011.09.005
Fullana, M. A. ; Alonso, P. ; Gratacòs, M. ; Jaurrieta, N. ; Jiménez-Murcia, S. ; Segalàs, C. ; Real, E. ; Estivill, Xavier P. ; Menchón, J. M. / Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder. In: European Psychiatry. 2012 ; Vol. 27, No. 5. pp. 386-390.
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