Abstract
Background: Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD). Methods: One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed. Results: Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (. P=. 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (. P<. 0.0001) and a lower obsessions severity decrease from pre- to posttreatment (. P=. 0.046). Conclusion: Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.
| Original language | English |
|---|---|
| Pages (from-to) | 386-390 |
| Number of pages | 5 |
| Journal | European Psychiatry |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jul 2012 |
| Externally published | Yes |
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Keywords
- BDNF
- Cognitive-behavior therapy
- Extinction
- Genetics
- Obsessive-compulsive disorder
- Val66Met
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder. / Fullana, M. A.; Alonso, P.; Gratacòs, M.; Jaurrieta, N.; Jiménez-Murcia, S.; Segalàs, C.; Real, E.; Estivill, Xavier P.; Menchón, J. M.
In: European Psychiatry, Vol. 27, No. 5, 07.2012, p. 386-390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder
AU - Fullana, M. A.
AU - Alonso, P.
AU - Gratacòs, M.
AU - Jaurrieta, N.
AU - Jiménez-Murcia, S.
AU - Segalàs, C.
AU - Real, E.
AU - Estivill, Xavier P.
AU - Menchón, J. M.
PY - 2012/7
Y1 - 2012/7
N2 - Background: Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD). Methods: One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed. Results: Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (. P=. 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (. P<. 0.0001) and a lower obsessions severity decrease from pre- to posttreatment (. P=. 0.046). Conclusion: Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.
AB - Background: Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD). Methods: One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed. Results: Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (. P=. 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (. P<. 0.0001) and a lower obsessions severity decrease from pre- to posttreatment (. P=. 0.046). Conclusion: Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.
KW - BDNF
KW - Cognitive-behavior therapy
KW - Extinction
KW - Genetics
KW - Obsessive-compulsive disorder
KW - Val66Met
UR - http://www.scopus.com/inward/record.url?scp=84859600363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859600363&partnerID=8YFLogxK
U2 - 10.1016/j.eurpsy.2011.09.005
DO - 10.1016/j.eurpsy.2011.09.005
M3 - Article
C2 - 22153732
AN - SCOPUS:84859600363
VL - 27
SP - 386
EP - 390
JO - European Psychiatry
JF - European Psychiatry
SN - 0924-9338
IS - 5
ER -