Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families

Candidate Gene Association Resource (CARe) Consortium

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background - Admixture mapping of lipids was followed-up by family-based association analysis to identify variants for cardiovascular disease in African Americans. Methods and Results - The present study conducted admixture mapping analysis for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. The analysis was performed in 1905 unrelated African American subjects from the National Heart, Lung and Blood Institute's Family Blood Pressure Program (FBPP). Regions showing admixture evidence were followed-up with family-based association analysis in 3556 African American subjects from the FBPP. The admixture mapping and family-based association analyses were adjusted for age, age2, sex, body mass index, and genome-wide mean ancestry to minimize the confounding caused by population stratification. Regions that were suggestive of local ancestry association evidence were found on chromosomes 7 (low-density lipoprotein cholesterol), 8 (high-density lipoprotein cholesterol), 14 (triglycerides), and 19 (total cholesterol and triglycerides). In the fine-mapping analysis, 52 939 single-nucleotide polymorphisms (SNPs) were tested and 11 SNPs (8 independent SNPs) showed nominal significant association with high-density lipoprotein cholesterol (2 SNPs), low-density lipoprotein cholesterol (4 SNPs), and triglycerides (5 SNPs). The family data were used in the fine-mapping to identify SNPs that showed novel associations with lipids and regions, including genes with known associations for cardiovascular disease. Conclusions - This study identified regions on chromosomes 7, 8, 14, and 19 and 11 SNPs from the fine-mapping analysis that were associated with high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides for further studies of cardiovascular disease in African Americans.

Original languageEnglish
Pages (from-to)106-113
Number of pages8
JournalCirculation: Cardiovascular Genetics
Volume8
Issue number1
DOIs
Publication statusPublished - 4 Feb 2015
Externally publishedYes

Fingerprint

African Americans
Single Nucleotide Polymorphism
LDL Cholesterol
HDL Cholesterol
Triglycerides
Chromosomes, Human, Pair 7
Cardiovascular Diseases
Cholesterol
HDL2 Lipoprotein
Blood Pressure
National Heart, Lung, and Blood Institute (U.S.)
Lipids
Chromosomes, Human, Pair 8
low density lipoprotein triglyceride
Body Mass Index
Genome
Population
Genes

Keywords

  • admixture mapping
  • African Americans
  • association studies
  • genetics
  • lipids

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Cite this

Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families. / Candidate Gene Association Resource (CARe) Consortium.

In: Circulation: Cardiovascular Genetics, Vol. 8, No. 1, 04.02.2015, p. 106-113.

Research output: Contribution to journalArticle

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abstract = "Background - Admixture mapping of lipids was followed-up by family-based association analysis to identify variants for cardiovascular disease in African Americans. Methods and Results - The present study conducted admixture mapping analysis for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. The analysis was performed in 1905 unrelated African American subjects from the National Heart, Lung and Blood Institute's Family Blood Pressure Program (FBPP). Regions showing admixture evidence were followed-up with family-based association analysis in 3556 African American subjects from the FBPP. The admixture mapping and family-based association analyses were adjusted for age, age2, sex, body mass index, and genome-wide mean ancestry to minimize the confounding caused by population stratification. Regions that were suggestive of local ancestry association evidence were found on chromosomes 7 (low-density lipoprotein cholesterol), 8 (high-density lipoprotein cholesterol), 14 (triglycerides), and 19 (total cholesterol and triglycerides). In the fine-mapping analysis, 52 939 single-nucleotide polymorphisms (SNPs) were tested and 11 SNPs (8 independent SNPs) showed nominal significant association with high-density lipoprotein cholesterol (2 SNPs), low-density lipoprotein cholesterol (4 SNPs), and triglycerides (5 SNPs). The family data were used in the fine-mapping to identify SNPs that showed novel associations with lipids and regions, including genes with known associations for cardiovascular disease. Conclusions - This study identified regions on chromosomes 7, 8, 14, and 19 and 11 SNPs from the fine-mapping analysis that were associated with high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides for further studies of cardiovascular disease in African Americans.",
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AU - Tang, Hua

AU - Feng, Tao

AU - Tayo, Bamidele

AU - Morrison, Alanna C.

AU - Kardia, Sharon L R

AU - Hanis, Craig L.

AU - Arnett, Donna K.

AU - Hunt, Steven

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