Vacuolar-type H+-ATPase distribution in unstimulated and acetylcholine-activated isolated human eccrine sweat glands

D. L. Bovell, M. T. Clunes, E. Roussa, J. Burry, H. Y. Elder

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The presence and cellular distribution of subunits of the V1 sector of the vacuolar-type H+-ATPase (V-ATPase) was investigated in isolated human eccrine sweat glands. In every instance, V-ATPase was located in the cytoplasm and apical membranes of the luminal cells of the reabsorptive duct segment. In the secretory coil, both diffuse and perinuclear staining was demonstrated in the secretory cells, with additional expression at the apical and basolateral membranes and on the inter-cellular canaliculi. There was no detectable difference in V-ATPase expression as a result of prior application of 100 μM acetylcholine.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalHistochemical Journal
Issue number7
Publication statusPublished - 1 Jan 2000


ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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