Vaccination in human solid tumors

Recent progress in the clinical arena

Giorgio Parmiani, Carolina Cimminiello, Cristina Maccalli, Vincenzo Russo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

Original languageEnglish
Title of host publicationCancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors
PublisherSpringer Berlin Heidelberg
Pages41-46
Number of pages6
ISBN (Electronic)9783662464106
ISBN (Print)9783662464090
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Fingerprint

Vaccination
Neoplasms
Cancer Vaccines
Immunomodulation
Neoplasm Antigens
Animal Models
Therapeutics

Keywords

  • Progression
  • Solid tumors
  • Vaccination

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Parmiani, G., Cimminiello, C., Maccalli, C., & Russo, V. (2015). Vaccination in human solid tumors: Recent progress in the clinical arena. In Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (pp. 41-46). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46410-6_2

Vaccination in human solid tumors : Recent progress in the clinical arena. / Parmiani, Giorgio; Cimminiello, Carolina; Maccalli, Cristina; Russo, Vincenzo.

Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors. Springer Berlin Heidelberg, 2015. p. 41-46.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parmiani, G, Cimminiello, C, Maccalli, C & Russo, V 2015, Vaccination in human solid tumors: Recent progress in the clinical arena. in Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors. Springer Berlin Heidelberg, pp. 41-46. https://doi.org/10.1007/978-3-662-46410-6_2
Parmiani G, Cimminiello C, Maccalli C, Russo V. Vaccination in human solid tumors: Recent progress in the clinical arena. In Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors. Springer Berlin Heidelberg. 2015. p. 41-46 https://doi.org/10.1007/978-3-662-46410-6_2
Parmiani, Giorgio ; Cimminiello, Carolina ; Maccalli, Cristina ; Russo, Vincenzo. / Vaccination in human solid tumors : Recent progress in the clinical arena. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors. Springer Berlin Heidelberg, 2015. pp. 41-46
@inbook{36f71f2088264487a04e5b59c75153f6,
title = "Vaccination in human solid tumors: Recent progress in the clinical arena",
abstract = "Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.",
keywords = "Progression, Solid tumors, Vaccination",
author = "Giorgio Parmiani and Carolina Cimminiello and Cristina Maccalli and Vincenzo Russo",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-662-46410-6_2",
language = "English",
isbn = "9783662464090",
pages = "41--46",
booktitle = "Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Vaccination in human solid tumors

T2 - Recent progress in the clinical arena

AU - Parmiani, Giorgio

AU - Cimminiello, Carolina

AU - Maccalli, Cristina

AU - Russo, Vincenzo

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

AB - Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

KW - Progression

KW - Solid tumors

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=84943408386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943408386&partnerID=8YFLogxK

U2 - 10.1007/978-3-662-46410-6_2

DO - 10.1007/978-3-662-46410-6_2

M3 - Chapter

SN - 9783662464090

SP - 41

EP - 46

BT - Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors

PB - Springer Berlin Heidelberg

ER -