Use of intravenous methylprednisolone in acute idiopathic thrombocytopenic purpura

Somasundaram Jayabose, Padma Patel, Sarla Inamdar, Renee Brilliant, Ravinder Mamtani

Research output: Contribution to journalArticle

18 Citations (Scopus)


Twenty newly diagnosed children with acute idiopathic thrombocytopenic purpura (ITP) with a platelet count (PC) of <20,000 were treated with intravenous methyl prednisolone (IVMP) 5 mg/kg/day in four divided doses until the platelet count increased to 50,000/mm3. They were then placed on oral prednisone at conventional doses for a total of three weeks of steroid therapy. The platelet counts increased by an average of 55,000/mm3 within 48 h of treatment. Within 72 h (day 3) of treatment all patients achieved a PC of >20,000/mm3. By day 5, all 20 patients achieved a PC of >50,000. IVMP is highly effective in rapidly raising the PC in acute ITP above the critical level of 20,000, thereby reducing the duration of risk for intracranial hemorrhage (ICH).

Original languageEnglish
Pages (from-to)133-135
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Issue number2
Publication statusPublished - 1 Jan 1987
Externally publishedYes



  • Idiopathic thrombocytopenic purpura
  • Intracranial hemorrhage
  • Intravenous methylprednisolone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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