Urban Chikungunya in the Middle East and North Africa

A systematic review

John M. Humphrey, Natalie B. Cleton, Chantal B.E.M. Reusken, Marshall J. Glesby, Marion P.G. Koopmans, Laith Aburaddad

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The epidemiology of Chikungunya virus (CHIKV) in the Middle East and North Africa (MENA) is not well characterized despite increasing recognition of its expanding infection and disease burden in recent years. Methodology / Principal findings: Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed records describing the human prevalence and incidence, CHIKV prevalence/infection rates in vectors, outbreaks, and reported cases for CHIKV across the MENA region. We identified 29 human seroprevalence measures, one human incidence study, one study reporting CHIKV infection rates in Aedes, and nine outbreaks and case reports/series reported in the MENA from 1970–2015. Overall, anti-CHIKV antibody or reports of autochthonous transmission were identified from 10 of 23 countries in the MENA region (Djibouti, Egypt, Iraq, Iran, Kuwait, Pakistan, Saudi Arabia, Somalia, Sudan, and Yemen), with seroprevalence measures among general populations (median 1.0%, range 0–43%) and acute febrile illness populations (median 9.8%, range 0–30%). Sudan reported the highest number of studies (n = 11) and the highest seroprevalence among general populations (median 12%, range 0–43%) and undifferentiated acute febrile illness populations (median 18%, range 10–23%). CHIKV outbreaks were reported from Djibouti, Pakistan, Sudan, and Yemen. Conclusions / Significance: Seroprevalence studies and outbreak reports suggest endemic transmission of urban cycle CHIKV in at least the Red Sea region and Pakistan. However, indications of seroprevalence despite a low quantity of CHIKV epidemiologic research from the region suggests that CHIKV transmission is currently underrecognized.

Original languageEnglish
Article numbere0005707
JournalPLoS Neglected Tropical Diseases
Volume11
Issue number6
DOIs
Publication statusPublished - 26 Jun 2017

Fingerprint

Chikungunya virus
Northern Africa
Eastern Africa
Middle East
Seroepidemiologic Studies
Sudan
Disease Outbreaks
Pakistan
Djibouti
Yemen
Population
Fever
Somalia
Guidelines
Kuwait
Indian Ocean
Iraq
Infectious Disease Transmission
Saudi Arabia
Aedes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Humphrey, J. M., Cleton, N. B., Reusken, C. B. E. M., Glesby, M. J., Koopmans, M. P. G., & Aburaddad, L. (2017). Urban Chikungunya in the Middle East and North Africa: A systematic review. PLoS Neglected Tropical Diseases, 11(6), [e0005707]. https://doi.org/10.1371/journal.pntd.0005707

Urban Chikungunya in the Middle East and North Africa : A systematic review. / Humphrey, John M.; Cleton, Natalie B.; Reusken, Chantal B.E.M.; Glesby, Marshall J.; Koopmans, Marion P.G.; Aburaddad, Laith.

In: PLoS Neglected Tropical Diseases, Vol. 11, No. 6, e0005707, 26.06.2017.

Research output: Contribution to journalArticle

Humphrey, John M. ; Cleton, Natalie B. ; Reusken, Chantal B.E.M. ; Glesby, Marshall J. ; Koopmans, Marion P.G. ; Aburaddad, Laith. / Urban Chikungunya in the Middle East and North Africa : A systematic review. In: PLoS Neglected Tropical Diseases. 2017 ; Vol. 11, No. 6.
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