Update on vaccines for melanoma patients

Vincenzo Russo, Cristina Maccalli, Lorenzo Pilla, Santo Raffaele Mercuri, Elena Orsenigo, Sylvain Mukenge, Marco Bregni, Giorgio Parmiani

Research output: Contribution to journalReview article

Abstract

Vaccination against melanoma has a long history but only recently has this therapeutic approach found a reliable scientific rationale. This review summarizes and updates the knowledge on the role of the main players in the vaccination strategy against metastatic melanoma, that is, the melanoma-associated antigens recognized by T and natural killer T lymphocytes, the conditions for the immune response to develop and the mechanisms that interfere with it. A commented list of the major vaccination trials whose results have been recently, published or are ongoing is also presented. Reasons for failure and potential success are underlined to offer a balanced view of this scientifically exciting but still clinically unrewarding field of investigation.

Original languageEnglish
Pages (from-to)195-207
Number of pages13
JournalExpert Review of Dermatology
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

Fingerprint

Melanoma
Vaccination
Vaccines
Melanoma-Specific Antigens
History
T-Lymphocytes
Therapeutics

Keywords

  • Melanoma
  • Melanoma vaccines
  • Melanoma-associated antigens
  • NKG2D
  • T lymphocytes
  • T-cell responses

ASJC Scopus subject areas

  • Dermatology

Cite this

Russo, V., Maccalli, C., Pilla, L., Mercuri, S. R., Orsenigo, E., Mukenge, S., ... Parmiani, G. (2008). Update on vaccines for melanoma patients. Expert Review of Dermatology, 3(2), 195-207. https://doi.org/10.1586/17469872.3.2.195

Update on vaccines for melanoma patients. / Russo, Vincenzo; Maccalli, Cristina; Pilla, Lorenzo; Mercuri, Santo Raffaele; Orsenigo, Elena; Mukenge, Sylvain; Bregni, Marco; Parmiani, Giorgio.

In: Expert Review of Dermatology, Vol. 3, No. 2, 04.2008, p. 195-207.

Research output: Contribution to journalReview article

Russo, V, Maccalli, C, Pilla, L, Mercuri, SR, Orsenigo, E, Mukenge, S, Bregni, M & Parmiani, G 2008, 'Update on vaccines for melanoma patients', Expert Review of Dermatology, vol. 3, no. 2, pp. 195-207. https://doi.org/10.1586/17469872.3.2.195
Russo V, Maccalli C, Pilla L, Mercuri SR, Orsenigo E, Mukenge S et al. Update on vaccines for melanoma patients. Expert Review of Dermatology. 2008 Apr;3(2):195-207. https://doi.org/10.1586/17469872.3.2.195
Russo, Vincenzo ; Maccalli, Cristina ; Pilla, Lorenzo ; Mercuri, Santo Raffaele ; Orsenigo, Elena ; Mukenge, Sylvain ; Bregni, Marco ; Parmiani, Giorgio. / Update on vaccines for melanoma patients. In: Expert Review of Dermatology. 2008 ; Vol. 3, No. 2. pp. 195-207.
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