Understanding the Obesity Paradox in Type 2 Diabetes Mellitus

P. Costanzo, D. Lai, Stephen Atkin

Research output: Contribution to journalReview article


The term “obesity paradox” corresponds to the research observation that overweight or obese patients may counterintuitively have a survival benefit once a disease is established. This appears also true in type 2 diabetes mellitus, where it has been shown that being overweight or obese is associated with better survival. The reasons behind this paradox remain unclear but likely derive from an intricate relationship between insulin resistance, fat storage, and inflammatory responses in type 2 diabetes. In this review, we look at what the potential mechanisms may be underlying this paradox.

Original languageEnglish
JournalCurrent Cardiovascular Risk Reports
Issue number7
Publication statusPublished - 16 Jul 2015
Externally publishedYes



  • Body mass index
  • Insulin resistance
  • Obesity
  • Obesity paradox
  • Overweight
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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