Type 2 diabetes is associated with postprandial amino acid measures

Dennis O. Mook-Kanamori, Renée De Mutsert, Patrick C N Rensen, Cornelia Prehn, Jerzy Adamski, Martin Den Heijer, Saskia Le Cessie, Karsten Suhre, Frits R. Rosendaal, Ko Willems Van Dijk

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12 Citations (Scopus)


Most studies examining the association between type 2 diabetes (T2D) and amino acids have focused on fasting concentrations. We hypothesized that, besides fasting concentrations, amino acid responses to a standardized meal challenge are also associated with T2D. In a cross-sectional study of 525 participants (165 newly-diagnosed T2D, 186 newly-diagnosed impaired fasting glycaemia, and 174 normal fasting glucose), we examined postprandial amino acid concentrations and the responses (defined as the concentrations and responses 150 min after a standardized meal) of fourteen amino acids in relation to T2D. T2D was associated with lower postprandial concentration of seven amino acids compared to the normal fasting glucose group (lowest effect estimate for serine: -0.54 standard deviations (SD) (95% CI: -0.77, -0.32)), and higher concentrations of phenylalanine, tryptophan, tyrosine and (iso-)leucine (highest effect estimate for (iso-)leucine: 0.44 SD (95% CI: 0.20, 0.67)). Regarding the meal responses, T2D was associated with lower responses of seven amino acids (ranging from -0.55 SD ((95% CI): -0.78, -0.33) for serine to -0.25 SD ((95% CI: -0.45, -0.02) for ornithine). We conclude that T2D is associated with postprandial concentrations of amino acids and a reduced amino acid meal response, indicating that these measures may also be potential markers of T2D.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalArchives of Biochemistry and Biophysics
Publication statusPublished - 1 Jan 2016
Externally publishedYes



  • Amino acids
  • Epidemiology
  • Meal response
  • Metabolomics
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

Mook-Kanamori, D. O., De Mutsert, R., Rensen, P. C. N., Prehn, C., Adamski, J., Den Heijer, M., Le Cessie, S., Suhre, K., Rosendaal, F. R., & Dijk, K. W. V. (2016). Type 2 diabetes is associated with postprandial amino acid measures. Archives of Biochemistry and Biophysics, 589, 138-144. https://doi.org/10.1016/j.abb.2015.08.003