Tying malaria and microRNAs: From the biology to future diagnostic perspectives

Mercedes Rubio, Quique Bassat, Xavier P. Estivill, Alfredo Mayor

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.

Original languageEnglish
Article number1222
JournalMalaria Journal
Volume15
Issue number1
DOIs
Publication statusPublished - 15 Mar 2016

Fingerprint

MicroRNAs
Malaria
Biomarkers
Virus Diseases
Communicable Diseases
Morbidity
Wounds and Injuries
Therapeutics
Pharmaceutical Preparations

Keywords

  • Biomarker
  • Diagnosis
  • Disease
  • Malaria
  • MicroRNA
  • Severity

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Tying malaria and microRNAs : From the biology to future diagnostic perspectives. / Rubio, Mercedes; Bassat, Quique; Estivill, Xavier P.; Mayor, Alfredo.

In: Malaria Journal, Vol. 15, No. 1, 1222, 15.03.2016.

Research output: Contribution to journalReview article

Rubio, Mercedes ; Bassat, Quique ; Estivill, Xavier P. ; Mayor, Alfredo. / Tying malaria and microRNAs : From the biology to future diagnostic perspectives. In: Malaria Journal. 2016 ; Vol. 15, No. 1.
@article{a4c0d5c674bb45898317d2fee9fac1e8,
title = "Tying malaria and microRNAs: From the biology to future diagnostic perspectives",
abstract = "Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.",
keywords = "Biomarker, Diagnosis, Disease, Malaria, MicroRNA, Severity",
author = "Mercedes Rubio and Quique Bassat and Estivill, {Xavier P.} and Alfredo Mayor",
year = "2016",
month = "3",
day = "15",
doi = "10.1186/s12936-016-1222-9",
language = "English",
volume = "15",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Tying malaria and microRNAs

T2 - From the biology to future diagnostic perspectives

AU - Rubio, Mercedes

AU - Bassat, Quique

AU - Estivill, Xavier P.

AU - Mayor, Alfredo

PY - 2016/3/15

Y1 - 2016/3/15

N2 - Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.

AB - Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.

KW - Biomarker

KW - Diagnosis

KW - Disease

KW - Malaria

KW - MicroRNA

KW - Severity

UR - http://www.scopus.com/inward/record.url?scp=84961177028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961177028&partnerID=8YFLogxK

U2 - 10.1186/s12936-016-1222-9

DO - 10.1186/s12936-016-1222-9

M3 - Review article

C2 - 26979504

AN - SCOPUS:84961177028

VL - 15

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

IS - 1

M1 - 1222

ER -