Turnover of AU-rich-containing mRNAs during stress

A matter of survival

Christopher von Roretz, Sergio di Marco, Rachid Mazroui, Imed Gallouzi

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Cells undergo various adaptive measures in response to stress. Among these are specific changes in the posttranscriptional regulation of various genes. In particular, the turnover of mRNA is modified to either increase or decrease the abundance of certain target messages. Some of the best-studied mRNAs that are affected by stress are those that contain adenine/uridine-rich elements (AREs) in their 3′-untranslated regions. ARE-containing mRNAs are involved in many important cellular processes and are normally labile, but in response to stress they are differentially regulated through the concerted efforts of ARE-binding proteins (AUBPs) such as HuR, AUF1, tristetraprolin, BRF1, and KSRP, along with microRNA-mediated effects. Additionally, the fate of ARE-containing mRNAs is modified by inducing their localization to stress granules or mRNA processing bodies. Coordination of these various mechanisms controls the turnover of ARE-containing mRNAs, and thereby enables proper responses to cellular stress. In this review, we discuss how AUBPs regulate their target mRNAs in response to stress, along with the involvement of cytoplasmic granules in this process.

Original languageEnglish
Pages (from-to)336-347
Number of pages12
JournalWiley Interdisciplinary Reviews: RNA
Volume2
Issue number3
DOIs
Publication statusPublished - May 2011
Externally publishedYes

Fingerprint

Uridine
Adenine
Messenger RNA
Tristetraprolin
Cytoplasmic Granules
3' Untranslated Regions
MicroRNAs
Carrier Proteins
Genes
Processing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Medicine(all)

Cite this

Turnover of AU-rich-containing mRNAs during stress : A matter of survival. / von Roretz, Christopher; di Marco, Sergio; Mazroui, Rachid; Gallouzi, Imed.

In: Wiley Interdisciplinary Reviews: RNA, Vol. 2, No. 3, 05.2011, p. 336-347.

Research output: Contribution to journalReview article

von Roretz, Christopher ; di Marco, Sergio ; Mazroui, Rachid ; Gallouzi, Imed. / Turnover of AU-rich-containing mRNAs during stress : A matter of survival. In: Wiley Interdisciplinary Reviews: RNA. 2011 ; Vol. 2, No. 3. pp. 336-347.
@article{f8d5695e8c6c419e8a8c1c92138f0319,
title = "Turnover of AU-rich-containing mRNAs during stress: A matter of survival",
abstract = "Cells undergo various adaptive measures in response to stress. Among these are specific changes in the posttranscriptional regulation of various genes. In particular, the turnover of mRNA is modified to either increase or decrease the abundance of certain target messages. Some of the best-studied mRNAs that are affected by stress are those that contain adenine/uridine-rich elements (AREs) in their 3′-untranslated regions. ARE-containing mRNAs are involved in many important cellular processes and are normally labile, but in response to stress they are differentially regulated through the concerted efforts of ARE-binding proteins (AUBPs) such as HuR, AUF1, tristetraprolin, BRF1, and KSRP, along with microRNA-mediated effects. Additionally, the fate of ARE-containing mRNAs is modified by inducing their localization to stress granules or mRNA processing bodies. Coordination of these various mechanisms controls the turnover of ARE-containing mRNAs, and thereby enables proper responses to cellular stress. In this review, we discuss how AUBPs regulate their target mRNAs in response to stress, along with the involvement of cytoplasmic granules in this process.",
author = "{von Roretz}, Christopher and {di Marco}, Sergio and Rachid Mazroui and Imed Gallouzi",
year = "2011",
month = "5",
doi = "10.1002/wrna.55",
language = "English",
volume = "2",
pages = "336--347",
journal = "Wiley interdisciplinary reviews. RNA",
issn = "1757-7004",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Turnover of AU-rich-containing mRNAs during stress

T2 - A matter of survival

AU - von Roretz, Christopher

AU - di Marco, Sergio

AU - Mazroui, Rachid

AU - Gallouzi, Imed

PY - 2011/5

Y1 - 2011/5

N2 - Cells undergo various adaptive measures in response to stress. Among these are specific changes in the posttranscriptional regulation of various genes. In particular, the turnover of mRNA is modified to either increase or decrease the abundance of certain target messages. Some of the best-studied mRNAs that are affected by stress are those that contain adenine/uridine-rich elements (AREs) in their 3′-untranslated regions. ARE-containing mRNAs are involved in many important cellular processes and are normally labile, but in response to stress they are differentially regulated through the concerted efforts of ARE-binding proteins (AUBPs) such as HuR, AUF1, tristetraprolin, BRF1, and KSRP, along with microRNA-mediated effects. Additionally, the fate of ARE-containing mRNAs is modified by inducing their localization to stress granules or mRNA processing bodies. Coordination of these various mechanisms controls the turnover of ARE-containing mRNAs, and thereby enables proper responses to cellular stress. In this review, we discuss how AUBPs regulate their target mRNAs in response to stress, along with the involvement of cytoplasmic granules in this process.

AB - Cells undergo various adaptive measures in response to stress. Among these are specific changes in the posttranscriptional regulation of various genes. In particular, the turnover of mRNA is modified to either increase or decrease the abundance of certain target messages. Some of the best-studied mRNAs that are affected by stress are those that contain adenine/uridine-rich elements (AREs) in their 3′-untranslated regions. ARE-containing mRNAs are involved in many important cellular processes and are normally labile, but in response to stress they are differentially regulated through the concerted efforts of ARE-binding proteins (AUBPs) such as HuR, AUF1, tristetraprolin, BRF1, and KSRP, along with microRNA-mediated effects. Additionally, the fate of ARE-containing mRNAs is modified by inducing their localization to stress granules or mRNA processing bodies. Coordination of these various mechanisms controls the turnover of ARE-containing mRNAs, and thereby enables proper responses to cellular stress. In this review, we discuss how AUBPs regulate their target mRNAs in response to stress, along with the involvement of cytoplasmic granules in this process.

UR - http://www.scopus.com/inward/record.url?scp=84855993636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855993636&partnerID=8YFLogxK

U2 - 10.1002/wrna.55

DO - 10.1002/wrna.55

M3 - Review article

VL - 2

SP - 336

EP - 347

JO - Wiley interdisciplinary reviews. RNA

JF - Wiley interdisciplinary reviews. RNA

SN - 1757-7004

IS - 3

ER -