Tumor necrosis factor promoter gene polymorphism associated with increased susceptibility to non-Hodgkin's lymphomas

Besma Bel Hadj Jrad, Amel Chatti, Adnene Laatiri, Slim Ben Ahmed, Abdelaziz Romdhane, Salem Ajimi, Lotfi Chouchane

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The tumor necrosis factor (TNF) is a pro-inflammatory cytokine involved in the severity of different immune-regulated diseases including autoimmune, infectious, and malignant diseases. Chronic immune system stimulation could be a potential etiologic factor in these diseases. Given the determining role of TNF acting early in the immune response, we investigated the effect of an inherited genetic polymorphism at TNF promoter (-308A/G) on a predisposition to non-Hodgkin's lymphoma (NHL). The genotype distribution was determined in 194 patients with NHL and 160 age- and sex-matched population-based controls. The comparison of the -308TNF genotypes between the NHL patients and the controls showed a significant excess of A/A genotype that is previously associated with higher TNF production. Indeed, the A/A genotype is present in 7.7% of the cases, but in only 2.5% of the controls. This genotype is associated with a significant increased risk of NHL (odds ratio = 3.63, P = 0.028). These results indicate that the genetic polymorphism which could lead to an increased TNF production or a neighboring gene within the MHC region may influence the susceptibility to NHL in Tunisian population. Other epidemiologic studies carried out in both the Tunisian population and elsewhere are needed to confirm this finding.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalEuropean Journal of Haematology
Issue number2
Publication statusPublished - 1 Feb 2007



  • Genetic polymorphism
  • Non-Hodgkin's lymphoma
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Hematology

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