T MRI in Alzheimer's Disease

Detection of Pathological Changes in Medial Temporal Lobe

Mohammad Haris, Anup Singh, Kejia Cai, Erin Mcardle, Matthew Fenty, Christos Davatzikos, John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Arijitt Borthakur

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND: The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T values correlated with the neurological diagnosis. METHODS: MRI was performed on AD (n= 48), MCI (n= 45), and age-matched control (n= 41), on a 1.5 Tesla Siemens clinical MRI scanner. T maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). RESULTS: GM and WM T values were 87.5 ± 1.2 ms and 80.5 ± 1.4 ms, respectively, in controls, 90.9 ± 1.3 ms and 84.1 ± 1.7 ms in MCI, and 91.9 ± .8 ms and 88.3 ± 1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T and 5% increased GM T. Compared to control, MCI individuals showed 4% increased T both in WM and GM. A 5% increased T was found in WM of AD over MCI. CONCLUSION: The increased T in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.

Original languageEnglish
JournalJournal of Neuroimaging
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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Temporal Lobe
Alzheimer Disease
Magnetic Resonance Spectroscopy
Leukoencephalopathies
Brain Diseases
Early Diagnosis
Cognitive Dysfunction
White Matter
Gray Matter

Keywords

  • Alzheimer's disease
  • Medial temporal lobe
  • MRI
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

T MRI in Alzheimer's Disease : Detection of Pathological Changes in Medial Temporal Lobe. / Haris, Mohammad; Singh, Anup; Cai, Kejia; Mcardle, Erin; Fenty, Matthew; Davatzikos, Christos; Trojanowski, John Q.; Melhem, Elias R.; Clark, Christopher M.; Borthakur, Arijitt.

In: Journal of Neuroimaging, Vol. 21, No. 2, 04.2011.

Research output: Contribution to journalArticle

Haris, M, Singh, A, Cai, K, Mcardle, E, Fenty, M, Davatzikos, C, Trojanowski, JQ, Melhem, ER, Clark, CM & Borthakur, A 2011, 'T MRI in Alzheimer's Disease: Detection of Pathological Changes in Medial Temporal Lobe', Journal of Neuroimaging, vol. 21, no. 2. https://doi.org/10.1111/j.1552-6569.2010.00467.x
Haris, Mohammad ; Singh, Anup ; Cai, Kejia ; Mcardle, Erin ; Fenty, Matthew ; Davatzikos, Christos ; Trojanowski, John Q. ; Melhem, Elias R. ; Clark, Christopher M. ; Borthakur, Arijitt. / T MRI in Alzheimer's Disease : Detection of Pathological Changes in Medial Temporal Lobe. In: Journal of Neuroimaging. 2011 ; Vol. 21, No. 2.
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abstract = "BACKGROUND: The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values correlated with the neurological diagnosis. METHODS: MRI was performed on AD (n= 48), MCI (n= 45), and age-matched control (n= 41), on a 1.5 Tesla Siemens clinical MRI scanner. T1ρ maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T1ρ values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). RESULTS: GM and WM T1ρ values were 87.5 ± 1.2 ms and 80.5 ± 1.4 ms, respectively, in controls, 90.9 ± 1.3 ms and 84.1 ± 1.7 ms in MCI, and 91.9 ± .8 ms and 88.3 ± 1.3 ms in AD cohorts. Compared to control, AD patients showed 9{\%} increased WM T1ρ and 5{\%} increased GM T1ρ. Compared to control, MCI individuals showed 4{\%} increased T1ρ both in WM and GM. A 5{\%} increased T1ρ was found in WM of AD over MCI. CONCLUSION: The increased T1ρ in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.",
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AU - Fenty, Matthew

AU - Davatzikos, Christos

AU - Trojanowski, John Q.

AU - Melhem, Elias R.

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N2 - BACKGROUND: The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values correlated with the neurological diagnosis. METHODS: MRI was performed on AD (n= 48), MCI (n= 45), and age-matched control (n= 41), on a 1.5 Tesla Siemens clinical MRI scanner. T1ρ maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T1ρ values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). RESULTS: GM and WM T1ρ values were 87.5 ± 1.2 ms and 80.5 ± 1.4 ms, respectively, in controls, 90.9 ± 1.3 ms and 84.1 ± 1.7 ms in MCI, and 91.9 ± .8 ms and 88.3 ± 1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T1ρ and 5% increased GM T1ρ. Compared to control, MCI individuals showed 4% increased T1ρ both in WM and GM. A 5% increased T1ρ was found in WM of AD over MCI. CONCLUSION: The increased T1ρ in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.

AB - BACKGROUND: The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values correlated with the neurological diagnosis. METHODS: MRI was performed on AD (n= 48), MCI (n= 45), and age-matched control (n= 41), on a 1.5 Tesla Siemens clinical MRI scanner. T1ρ maps were generated by fitting each pixel's intensity as a function of the duration of the spin-lock pulse. T1ρ values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). RESULTS: GM and WM T1ρ values were 87.5 ± 1.2 ms and 80.5 ± 1.4 ms, respectively, in controls, 90.9 ± 1.3 ms and 84.1 ± 1.7 ms in MCI, and 91.9 ± .8 ms and 88.3 ± 1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T1ρ and 5% increased GM T1ρ. Compared to control, MCI individuals showed 4% increased T1ρ both in WM and GM. A 5% increased T1ρ was found in WM of AD over MCI. CONCLUSION: The increased T1ρ in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.

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