Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy

Rayaz Malik, S. Tesfaye, S. D. Thompson, A. Veves, A. Hunter, A. K. Sharma, J. D. Ward, A. J M Boulton

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Morphometric techniques were employed to assess perineurial capillary abnormalities in the sural nerve of 20 diabetic patients with neuropathy and 10 normal control subjects. Structural abnormalities were related to quantitative neurophysiological and neuropathological measures of neuropathy. Perineurial capillary endothelial cell area (P < 0.001) and endothelial cell profile number (P < 0.01) were increased and luminal area (P < 0.001) was reduced in diabetic patients when compared with control subjects. A significant relationship was observed between endothelial cell hyperplasia and measures of neuropathic severity. These findings provide evidence for perineurial capillary luminal occlusion due primarily to both endothelial cell hypertrophy and hyperplasia. Such a reduction in luminal size is expected to reduce transperineurial and hence endoneurial blood flow, resulting in endoneurial hypoxia and hence human diabetic neuropathy.

Original languageEnglish
Pages (from-to)236-245
Number of pages10
JournalMicrovascular Research
Volume48
Issue number2
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Sural Nerve
Diabetic Neuropathies
Endothelial cells
Endothelial Cells
Hyperplasia
Hypertrophy
Blood
Cell Count
sural

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

Cite this

Malik, R., Tesfaye, S., Thompson, S. D., Veves, A., Hunter, A., Sharma, A. K., ... Boulton, A. J. M. (1994). Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy. Microvascular Research, 48(2), 236-245. https://doi.org/10.1006/mvre.1994.1051

Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy. / Malik, Rayaz; Tesfaye, S.; Thompson, S. D.; Veves, A.; Hunter, A.; Sharma, A. K.; Ward, J. D.; Boulton, A. J M.

In: Microvascular Research, Vol. 48, No. 2, 1994, p. 236-245.

Research output: Contribution to journalArticle

Malik, R, Tesfaye, S, Thompson, SD, Veves, A, Hunter, A, Sharma, AK, Ward, JD & Boulton, AJM 1994, 'Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy', Microvascular Research, vol. 48, no. 2, pp. 236-245. https://doi.org/10.1006/mvre.1994.1051
Malik, Rayaz ; Tesfaye, S. ; Thompson, S. D. ; Veves, A. ; Hunter, A. ; Sharma, A. K. ; Ward, J. D. ; Boulton, A. J M. / Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy. In: Microvascular Research. 1994 ; Vol. 48, No. 2. pp. 236-245.
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