Transient improvement of congenital lactic acidosis in a male infant with pyruvate decarboxylase deficiency treated with dichloroacetate

Peter P. Tóth, Hatem El-Shanti, Sandra Eivins, William J. Rhead, Jonathan M. Klein

Research output: Contribution to journalArticle

19 Citations (Scopus)


A comatose male newborn infant with congenital lactic acidosis caused by pyruvate decarboxylase deficiency was treated with dichloroacetate (DCA), which stimulated an 88% drop in serum lactate concentration and reversed his coma. The response to DCA was temporary and the lactic acidosis worsened until his death, but DCA may confer more lasting benefit in less severely affected infants.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalThe Journal of Pediatrics
Issue number3
Publication statusPublished - 1993
Externally publishedYes


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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