Transforming growth factor beta and excess burden of renal disease.

Phyllis August, Vijay Sharma, Ruchuang Ding, Joseph E. Schwartz, Manikkam Suthanthiran

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Abstract

End-stage renal disease (ESRD) is more frequent in African Americans (blacks) compared to whites. Because renal fibrosis is a correlate of progressive renal failure and a dominant feature of ESRD, and because transforming growth factor beta 1 (TGF-beta1) can induce fibrosis and renal insufficiency, we hypothesized that TGF-beta1 hyperexpression is more frequent in blacks compared to whites. We measured circulating levels of TGF-beta1 in black and white patients with ESRD, hypertension, and in normal patients. We demonstrated that circulating levels of TGF-beta1 are higher in black ESRD patients, hypertensive patients, and normal control patients compared to their white counterparts. Our preliminary genetic analyses suggest that TGF-beta1 DNA polymorphisms are different in blacks and whites. Our observations of hyperexpression of TGF-beta1 in blacks suggest a mechanism for the increased prevalence of renal failure and hypertensive target organ damage in this population.

Original languageEnglish
Pages (from-to)61-72
Number of pages12
JournalTransactions of the American Clinical and Climatological Association
Volume120
Publication statusPublished - 1 Dec 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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