Transforming growth factor beta and excess burden of renal disease.

Phyllis August, Vijay Sharma, Ruchuang Ding, Joseph E. Schwartz, Manikkam Suthanthiran

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

End-stage renal disease (ESRD) is more frequent in African Americans (blacks) compared to whites. Because renal fibrosis is a correlate of progressive renal failure and a dominant feature of ESRD, and because transforming growth factor beta 1 (TGF-beta1) can induce fibrosis and renal insufficiency, we hypothesized that TGF-beta1 hyperexpression is more frequent in blacks compared to whites. We measured circulating levels of TGF-beta1 in black and white patients with ESRD, hypertension, and in normal patients. We demonstrated that circulating levels of TGF-beta1 are higher in black ESRD patients, hypertensive patients, and normal control patients compared to their white counterparts. Our preliminary genetic analyses suggest that TGF-beta1 DNA polymorphisms are different in blacks and whites. Our observations of hyperexpression of TGF-beta1 in blacks suggest a mechanism for the increased prevalence of renal failure and hypertensive target organ damage in this population.

Original languageEnglish
Pages (from-to)61-72
Number of pages12
JournalTransactions of the American Clinical and Climatological Association
Volume120
Publication statusPublished - 1 Dec 2009
Externally publishedYes

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Transforming Growth Factor beta
Kidney
Chronic Kidney Failure
Renal Insufficiency
Fibrosis
Renal Hypertension
African Americans
DNA
Population
hydroquinone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Transforming growth factor beta and excess burden of renal disease. / August, Phyllis; Sharma, Vijay; Ding, Ruchuang; Schwartz, Joseph E.; Suthanthiran, Manikkam.

In: Transactions of the American Clinical and Climatological Association, Vol. 120, 01.12.2009, p. 61-72.

Research output: Contribution to journalArticle

August, Phyllis ; Sharma, Vijay ; Ding, Ruchuang ; Schwartz, Joseph E. ; Suthanthiran, Manikkam. / Transforming growth factor beta and excess burden of renal disease. In: Transactions of the American Clinical and Climatological Association. 2009 ; Vol. 120. pp. 61-72.
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