Toxic effects of metals: Modulation of intracellular calcium homeostasis

A. M. Florea, Dietrich Busselberg

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Metals and metalloids with their organic derivatives are part of the environment occurring naturally or being introduced upon human activity (e.g. industry, agriculture or medicine). Even if they are useful for humans, these chemicals could be highly toxic (e.g. mercury, lead, arsenic, tin) acting as neurotoxins or carcinogens. Several human cases of metal derived intoxication have been documented resulting in health complications or ending with death. The mechanisms of toxicity are not well understood. Since calcium is a universal second messenger in all cell types it is a good candidate to investigate how changes in the intracellular calcium homeostasis are involved in metal(loid) toxicity. In this mini-overview the interaction of metallic species with channel proteins at the outer cell membrane, as well as with calcium release sides from the calcium stores and the impairment with calcium extrusion mechanism is discussed.

Original languageEnglish
Pages (from-to)757-760
Number of pages4
JournalMaterialwissenschaft und Werkstofftechnik
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

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Keywords

  • Calcium channels
  • Calcium stores
  • Intracellular calcium
  • Metalls and metalloids

ASJC Scopus subject areas

  • Materials Science(all)
  • Biotechnology
  • Biochemistry

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