TNFA -308G>A in two international population-based cohorts and risk of asthma

F. Castro-Giner, M. Kogevinas, M. Mächler, R. De Cid, K. Van Steen, M. Imboden, C. Schindler, W. Berger, J. R. Gonzalez, K. A. Franklin, C. Janson, D. Jarvis, E. Omenaas, P. Burney, T. Rochat, Xavier P. Estivill, J. M. Antó, M. Wjst, N. M. Probst-Hensch

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Genetic association studies have related the tumour necrosis factor-α gene (TNFA) guanine to adenine substitution of nucleotide -308 (-308G>A) polymorphism to increased risk of asthma, but results are inconsistent. The aim of the present study was to test whether two single-nucleotide polymorphisms, of TNFA and of the lymphotoxin-α gene (LTA), are associated with asthma, bronchial hyperresponsiveness and atopy in adults, by combining the results of two large population-based multicentric studies and conducting a meta-analysis of previously published studies. The European Community Respiratory Health Survey (ECRHS) and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) used comparable protocols, including questionnaires for respiratory symptoms and measures of lung function and atopy. DNA samples from 11,136 participants were genotyped at TNFA -308 and LTA 252. Logistic regression employing fixed and random effects models and nonparametric techniques were used. The prevalence of asthma was 6%. The TNFA -308G>A polymorphism was associated with increased asthma prevalence and with bronchial hyperresponsiveness. No consistent association was found for atopy. The LTA 252A>G polymorphism was not associated with any of the outcomes. A meta-analysis of 17 studies showed an increased asthma risk for the TNFA -308 adenine allele. The tumour necrosis factor-α gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy. These results are supported by a meta-analysis of previously published studies. Copyright

Original languageEnglish
Pages (from-to)350-361
Number of pages12
JournalEuropean Respiratory Journal
Volume32
Issue number2
DOIs
Publication statusPublished - Aug 2008
Externally publishedYes

Fingerprint

Asthma
Tumor Necrosis Factor-alpha
Population
Genes
Meta-Analysis
Lymphotoxin-alpha
Adenine Nucleotides
Air Pollution
Guanine
Genetic Association Studies
Adenine
European Union
Health Surveys
Lung Diseases
Single Nucleotide Polymorphism
Heart Diseases
Cohort Studies
Nucleotides
Logistic Models
Alleles

Keywords

  • Asthma
  • Genetics
  • Lymphotoxin-α
  • Polymorphism
  • Tumour necrosis factor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Castro-Giner, F., Kogevinas, M., Mächler, M., De Cid, R., Van Steen, K., Imboden, M., ... Probst-Hensch, N. M. (2008). TNFA -308G>A in two international population-based cohorts and risk of asthma. European Respiratory Journal, 32(2), 350-361. https://doi.org/10.1183/09031936.00155607

TNFA -308G>A in two international population-based cohorts and risk of asthma. / Castro-Giner, F.; Kogevinas, M.; Mächler, M.; De Cid, R.; Van Steen, K.; Imboden, M.; Schindler, C.; Berger, W.; Gonzalez, J. R.; Franklin, K. A.; Janson, C.; Jarvis, D.; Omenaas, E.; Burney, P.; Rochat, T.; Estivill, Xavier P.; Antó, J. M.; Wjst, M.; Probst-Hensch, N. M.

In: European Respiratory Journal, Vol. 32, No. 2, 08.2008, p. 350-361.

Research output: Contribution to journalArticle

Castro-Giner, F, Kogevinas, M, Mächler, M, De Cid, R, Van Steen, K, Imboden, M, Schindler, C, Berger, W, Gonzalez, JR, Franklin, KA, Janson, C, Jarvis, D, Omenaas, E, Burney, P, Rochat, T, Estivill, XP, Antó, JM, Wjst, M & Probst-Hensch, NM 2008, 'TNFA -308G>A in two international population-based cohorts and risk of asthma', European Respiratory Journal, vol. 32, no. 2, pp. 350-361. https://doi.org/10.1183/09031936.00155607
Castro-Giner F, Kogevinas M, Mächler M, De Cid R, Van Steen K, Imboden M et al. TNFA -308G>A in two international population-based cohorts and risk of asthma. European Respiratory Journal. 2008 Aug;32(2):350-361. https://doi.org/10.1183/09031936.00155607
Castro-Giner, F. ; Kogevinas, M. ; Mächler, M. ; De Cid, R. ; Van Steen, K. ; Imboden, M. ; Schindler, C. ; Berger, W. ; Gonzalez, J. R. ; Franklin, K. A. ; Janson, C. ; Jarvis, D. ; Omenaas, E. ; Burney, P. ; Rochat, T. ; Estivill, Xavier P. ; Antó, J. M. ; Wjst, M. ; Probst-Hensch, N. M. / TNFA -308G>A in two international population-based cohorts and risk of asthma. In: European Respiratory Journal. 2008 ; Vol. 32, No. 2. pp. 350-361.
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