Three-dimensional organization of block copolymers on "DNA- minimal" scaffolds

Christopher K. McLaughlin, Graham D. Hamblin, Kevin D. Hänni, Justin W. Conway, Manoj K. Nayak, Karina M M Carneiro, Hassan S. Bazzi, Hanadi F. Sleiman

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Here, we introduce a 3D-DNA construction method that assembles a minimum number of DNA strands in quantitative yield, to give a scaffold with a large number of single-stranded arms. This DNA frame is used as a core structure to organize other functional materials in 3D as the shell. We use the ring-opening metathesis polymerization (ROMP) to generate block copolymers that are covalently attached to DNA strands. Site-specific hybridization of these DNA-polymer chains on the single-stranded arms of the 3D-DNA scaffold gives efficient access to DNA-block copolymer cages. These biohybrid cages possess polymer chains that are programmably positioned in three dimensions on a DNA core and display increased nuclease resistance as compared to unfunctionalized DNA cages.

Original languageEnglish
Pages (from-to)4280-4286
Number of pages7
JournalJournal of the American Chemical Society
Volume134
Issue number9
DOIs
Publication statusPublished - 7 Mar 2012

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Scaffolds
Block copolymers
DNA
Polymers
Functional materials
Ring opening polymerization
Polymerization
Display devices

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

McLaughlin, C. K., Hamblin, G. D., Hänni, K. D., Conway, J. W., Nayak, M. K., Carneiro, K. M. M., ... Sleiman, H. F. (2012). Three-dimensional organization of block copolymers on "DNA- minimal" scaffolds. Journal of the American Chemical Society, 134(9), 4280-4286. https://doi.org/10.1021/ja210313p

Three-dimensional organization of block copolymers on "DNA- minimal" scaffolds. / McLaughlin, Christopher K.; Hamblin, Graham D.; Hänni, Kevin D.; Conway, Justin W.; Nayak, Manoj K.; Carneiro, Karina M M; Bazzi, Hassan S.; Sleiman, Hanadi F.

In: Journal of the American Chemical Society, Vol. 134, No. 9, 07.03.2012, p. 4280-4286.

Research output: Contribution to journalArticle

McLaughlin, CK, Hamblin, GD, Hänni, KD, Conway, JW, Nayak, MK, Carneiro, KMM, Bazzi, HS & Sleiman, HF 2012, 'Three-dimensional organization of block copolymers on "DNA- minimal" scaffolds', Journal of the American Chemical Society, vol. 134, no. 9, pp. 4280-4286. https://doi.org/10.1021/ja210313p
McLaughlin CK, Hamblin GD, Hänni KD, Conway JW, Nayak MK, Carneiro KMM et al. Three-dimensional organization of block copolymers on "DNA- minimal" scaffolds. Journal of the American Chemical Society. 2012 Mar 7;134(9):4280-4286. https://doi.org/10.1021/ja210313p
McLaughlin, Christopher K. ; Hamblin, Graham D. ; Hänni, Kevin D. ; Conway, Justin W. ; Nayak, Manoj K. ; Carneiro, Karina M M ; Bazzi, Hassan S. ; Sleiman, Hanadi F. / Three-dimensional organization of block copolymers on "DNA- minimal" scaffolds. In: Journal of the American Chemical Society. 2012 ; Vol. 134, No. 9. pp. 4280-4286.
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