Thiamine deficiency related microstructural brain changes in acute and acute-on-chronic liver failure of non-alcoholic etiology

Rakesh Kumar Gupta, Santosh K. Yadav, Vivek Anand Saraswat, Murali Rangan, Anshu Srivastava, Abhishek Yadav, Richa Trivedi, Surendra Kumar Yachha, Ram Kishore Singh Rathore

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background & aims: Mammillary body atrophy in alcoholic liver disease usually indicates thiamine deficiency. The purpose of this study was to explore the relationship among blood thiamine, mammillary bodies, major fiber bundle fractional anisotropy, and volume changes with diffusion tensor tractography in patients with acute and acute-on-chronic liver failure of non-alcoholic etiology. Methods: Blood thiamine, mammillary bodies, fiber bundle fractional anisotropy and volume of major fiber tracts were quantified from acute and acute-on-chronic liver failure patients and compared with healthy controls. In 7 acute liver failure patients, follow-up study was done after clinical recovery at 5 weeks. Results: Blood thiamine, mammillary bodies and fornix volume, and fornix fiber bundle fractional anisotropy were significantly decreased as compared to controls. Blood thiamine showed significant positive correlation with mammillary bodies' volume only. On follow-up study, acute liver failure patients showed significant reversibility only in blood thiamine level and mammillary bodies' volume. Conclusions: Mammillary bodies' volume changes are primarily a consequence of thiamine deficiency, which may secondarily result in microstructural changes in the fornix. These observable changes are known to be specific and may be reversible with restoration of blood thiamine level. These imaging changes may be used as imaging biomarker of thiamine deficiency in these patients in future.

Original languageEnglish
Pages (from-to)422-428
Number of pages7
JournalClinical Nutrition
Volume31
Issue number3
DOIs
Publication statusPublished - 1 Jun 2012
Externally publishedYes

Fingerprint

Mammillary Bodies
Thiamine Deficiency
Thiamine
Brain
Anisotropy
Acute Liver Failure
Alcoholic Liver Diseases
Diffusion Tensor Imaging
Acute-On-Chronic Liver Failure
Atrophy
Biomarkers

Keywords

  • Fiber bundle
  • Liver failure
  • Mammillary body volume
  • Thiamine deficiency

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

Cite this

Thiamine deficiency related microstructural brain changes in acute and acute-on-chronic liver failure of non-alcoholic etiology. / Gupta, Rakesh Kumar; Yadav, Santosh K.; Saraswat, Vivek Anand; Rangan, Murali; Srivastava, Anshu; Yadav, Abhishek; Trivedi, Richa; Yachha, Surendra Kumar; Rathore, Ram Kishore Singh.

In: Clinical Nutrition, Vol. 31, No. 3, 01.06.2012, p. 422-428.

Research output: Contribution to journalArticle

Gupta, RK, Yadav, SK, Saraswat, VA, Rangan, M, Srivastava, A, Yadav, A, Trivedi, R, Yachha, SK & Rathore, RKS 2012, 'Thiamine deficiency related microstructural brain changes in acute and acute-on-chronic liver failure of non-alcoholic etiology', Clinical Nutrition, vol. 31, no. 3, pp. 422-428. https://doi.org/10.1016/j.clnu.2011.11.018
Gupta, Rakesh Kumar ; Yadav, Santosh K. ; Saraswat, Vivek Anand ; Rangan, Murali ; Srivastava, Anshu ; Yadav, Abhishek ; Trivedi, Richa ; Yachha, Surendra Kumar ; Rathore, Ram Kishore Singh. / Thiamine deficiency related microstructural brain changes in acute and acute-on-chronic liver failure of non-alcoholic etiology. In: Clinical Nutrition. 2012 ; Vol. 31, No. 3. pp. 422-428.
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