The Saliva Metabolome in Association to Oral Health Status

C. Liebsch, V. Pitchika, C. Pink, S. Samietz, G. Kastenmüller, A. Artati, Karsten Suhre, J. Adamski, M. Nauck, H. Völzke, N. Friedrich, T. Kocher, B. Holtfreter, M. Pietzner

Research output: Contribution to journalArticle

Abstract

Periodontitis is one of the most prevalent oral diseases worldwide and is caused by multifactorial interactions between host and oral bacteria. Altered cellular metabolism of host and microbes releases a number of intermediary end products known as metabolites. There is an increasing interest in identifying metabolites from oral fluids such as saliva to widen the understanding of the complex pathogenesis of periodontitis. It is believed that some metabolites might serve as indicators toward early detection and screening of periodontitis and perhaps even for monitoring its prognosis in the future. Because contemporary periodontal screening methods are deficient, there is an urgent need for novel approaches in periodontal screening procedures. To this end, we associated oral parameters (clinical attachment level, periodontal probing depth, supragingival plaque, supragingival calculus, number of missing teeth, and removable denture) with a large set of salivary metabolites (n = 284) obtained by mass spectrometry among a subsample (n = 909) of nondiabetic participants from the Study of Health in Pomerania (SHIP-Trend-0). Linear regression analyses were performed in age-stratified groups and adjusted for potential confounders. A multifaceted image of associated metabolites (n = 107) was revealed with considerable differences according to age groups. In the young (20 to 39 y) and middle-aged (40 to 59 y) groups, metabolites were predominantly associated with periodontal variables, whereas among the older subjects (≥60 y), tooth loss was strongly associated with metabolite levels. Metabolites associated with periodontal variables were clearly linked to tissue destruction, host defense mechanisms, and bacterial metabolism. Across all age groups, the bacterial metabolite phenylacetate was significantly associated with periodontal variables. Our results revealed alterations of the salivary metabolome in association with age and oral health status. Among our comprehensive panel of metabolites, periodontitis was significantly associated with the bacterial metabolite phenylacetate, a promising substance for further biomarker research.

Original languageEnglish
JournalJournal of Dental Research
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Metabolome
Periodontitis
Oral Health
Saliva
Health Status
Age Groups
Mouth Diseases
Tooth Loss
Dentures
Calculi
Linear Models
Mass Spectrometry
Tooth
Biomarkers
Regression Analysis
Bacteria
Health
Research
phenylacetic acid

Keywords

  • bacteria
  • biomarkers
  • inflammation
  • metabolism
  • metabolomics
  • periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Liebsch, C., Pitchika, V., Pink, C., Samietz, S., Kastenmüller, G., Artati, A., ... Pietzner, M. (2019). The Saliva Metabolome in Association to Oral Health Status. Journal of Dental Research. https://doi.org/10.1177/0022034519842853

The Saliva Metabolome in Association to Oral Health Status. / Liebsch, C.; Pitchika, V.; Pink, C.; Samietz, S.; Kastenmüller, G.; Artati, A.; Suhre, Karsten; Adamski, J.; Nauck, M.; Völzke, H.; Friedrich, N.; Kocher, T.; Holtfreter, B.; Pietzner, M.

In: Journal of Dental Research, 01.01.2019.

Research output: Contribution to journalArticle

Liebsch, C, Pitchika, V, Pink, C, Samietz, S, Kastenmüller, G, Artati, A, Suhre, K, Adamski, J, Nauck, M, Völzke, H, Friedrich, N, Kocher, T, Holtfreter, B & Pietzner, M 2019, 'The Saliva Metabolome in Association to Oral Health Status', Journal of Dental Research. https://doi.org/10.1177/0022034519842853
Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmüller G, Artati A et al. The Saliva Metabolome in Association to Oral Health Status. Journal of Dental Research. 2019 Jan 1. https://doi.org/10.1177/0022034519842853
Liebsch, C. ; Pitchika, V. ; Pink, C. ; Samietz, S. ; Kastenmüller, G. ; Artati, A. ; Suhre, Karsten ; Adamski, J. ; Nauck, M. ; Völzke, H. ; Friedrich, N. ; Kocher, T. ; Holtfreter, B. ; Pietzner, M. / The Saliva Metabolome in Association to Oral Health Status. In: Journal of Dental Research. 2019.
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