The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis

Laura Wagstaff, Richard Kelwick, Julie Decock, Dylan R. Edwards

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other ADAMTSs has been linked to the pathogenesis of arthritis and cancer. Several ADAMTSs act as tumor or metastasis suppressors whose functions are lost either by mutation or epigenetic silencing during tumor progression. This review looks in depth at the involvement of ADAMTSs as positive and negative mediators in cancer growth and spread.

Original languageEnglish
Pages (from-to)1861-1872
Number of pages12
JournalFrontiers in Bioscience
Volume16
Issue number5
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

Fingerprint

Thrombospondins
Disintegrins
Metalloproteases
Tumors
Carcinogenesis
Neoplasm Metastasis
Military electronic countermeasures
Neoplasms
Peptide Hydrolases
Biological Phenomena
Degradation
Defects
Inborn Genetic Diseases
Organogenesis
Medical Genetics
Hemostasis
Epigenomics
Arthritis
Mutation
Growth

Keywords

  • ADAMTS
  • Angiogenesis
  • Metalloproteinase
  • Metastasis
  • Review
  • Thrombospondin type-1 repeat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis. / Wagstaff, Laura; Kelwick, Richard; Decock, Julie; Edwards, Dylan R.

In: Frontiers in Bioscience, Vol. 16, No. 5, 01.01.2011, p. 1861-1872.

Research output: Contribution to journalArticle

Wagstaff, Laura ; Kelwick, Richard ; Decock, Julie ; Edwards, Dylan R. / The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis. In: Frontiers in Bioscience. 2011 ; Vol. 16, No. 5. pp. 1861-1872.
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