The role of sodium channels in painful diabetic and idiopathic neuropathy

Giuseppe Lauria, Dan Ziegler, Rayaz Malik, Ingemar S.J. Merkies, Stephen G. Waxman, Catharina G. Faber

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presentation and course of painful neuropathies, as well as the response to available drugs, are highly variable and unpredictable, posing significant challenges in the management of patients. Experimental and clinical studies have suggested that polymorphisms and mutations in pain-related genes are involved in the facilitation or inhibition of nociception, and might modulate neuropathic pain and the response to analgesics in patients. Voltage-gated sodium channel genes are among the most relevant, due to the key role of these membrane proteins in the physiology of nociception and their involvement in the pathogenesis of idiopathic painful small fiber neuropathies. These compelling features make sodium channel candidate targets for a novel approach to painful diabetic and idiopathic neuropathies, which will hopefully allow a new classification of patients and more effective targeted treatments.

Original languageEnglish
Pages (from-to)538
Number of pages1
JournalCurrent Diabetes Reports
Volume14
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014

Fingerprint

Diabetic Neuropathies
Sodium Channels
Nociception
Analgesics
Voltage-Gated Sodium Channels
Neuralgia
Genes
Membrane Proteins
Epidemiology
Pain
Mutation
Pharmaceutical Preparations
Painful Neuropathy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The role of sodium channels in painful diabetic and idiopathic neuropathy. / Lauria, Giuseppe; Ziegler, Dan; Malik, Rayaz; Merkies, Ingemar S.J.; Waxman, Stephen G.; Faber, Catharina G.

In: Current Diabetes Reports, Vol. 14, No. 10, 01.10.2014, p. 538.

Research output: Contribution to journalReview article

Lauria, Giuseppe ; Ziegler, Dan ; Malik, Rayaz ; Merkies, Ingemar S.J. ; Waxman, Stephen G. ; Faber, Catharina G. / The role of sodium channels in painful diabetic and idiopathic neuropathy. In: Current Diabetes Reports. 2014 ; Vol. 14, No. 10. pp. 538.
@article{c92a91322746427d97d3ae7fbddf20c0,
title = "The role of sodium channels in painful diabetic and idiopathic neuropathy",
abstract = "Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presentation and course of painful neuropathies, as well as the response to available drugs, are highly variable and unpredictable, posing significant challenges in the management of patients. Experimental and clinical studies have suggested that polymorphisms and mutations in pain-related genes are involved in the facilitation or inhibition of nociception, and might modulate neuropathic pain and the response to analgesics in patients. Voltage-gated sodium channel genes are among the most relevant, due to the key role of these membrane proteins in the physiology of nociception and their involvement in the pathogenesis of idiopathic painful small fiber neuropathies. These compelling features make sodium channel candidate targets for a novel approach to painful diabetic and idiopathic neuropathies, which will hopefully allow a new classification of patients and more effective targeted treatments.",
author = "Giuseppe Lauria and Dan Ziegler and Rayaz Malik and Merkies, {Ingemar S.J.} and Waxman, {Stephen G.} and Faber, {Catharina G.}",
year = "2014",
month = "10",
day = "1",
doi = "10.1007/s11892-014-0538-5",
language = "English",
volume = "14",
pages = "538",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "10",

}

TY - JOUR

T1 - The role of sodium channels in painful diabetic and idiopathic neuropathy

AU - Lauria, Giuseppe

AU - Ziegler, Dan

AU - Malik, Rayaz

AU - Merkies, Ingemar S.J.

AU - Waxman, Stephen G.

AU - Faber, Catharina G.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presentation and course of painful neuropathies, as well as the response to available drugs, are highly variable and unpredictable, posing significant challenges in the management of patients. Experimental and clinical studies have suggested that polymorphisms and mutations in pain-related genes are involved in the facilitation or inhibition of nociception, and might modulate neuropathic pain and the response to analgesics in patients. Voltage-gated sodium channel genes are among the most relevant, due to the key role of these membrane proteins in the physiology of nociception and their involvement in the pathogenesis of idiopathic painful small fiber neuropathies. These compelling features make sodium channel candidate targets for a novel approach to painful diabetic and idiopathic neuropathies, which will hopefully allow a new classification of patients and more effective targeted treatments.

AB - Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presentation and course of painful neuropathies, as well as the response to available drugs, are highly variable and unpredictable, posing significant challenges in the management of patients. Experimental and clinical studies have suggested that polymorphisms and mutations in pain-related genes are involved in the facilitation or inhibition of nociception, and might modulate neuropathic pain and the response to analgesics in patients. Voltage-gated sodium channel genes are among the most relevant, due to the key role of these membrane proteins in the physiology of nociception and their involvement in the pathogenesis of idiopathic painful small fiber neuropathies. These compelling features make sodium channel candidate targets for a novel approach to painful diabetic and idiopathic neuropathies, which will hopefully allow a new classification of patients and more effective targeted treatments.

UR - http://www.scopus.com/inward/record.url?scp=84930278740&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930278740&partnerID=8YFLogxK

U2 - 10.1007/s11892-014-0538-5

DO - 10.1007/s11892-014-0538-5

M3 - Review article

C2 - 25142720

AN - SCOPUS:84919443732

VL - 14

SP - 538

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 10

ER -