The role of SERCA2a/PLN complex, Ca2+ homeostasis, and anti-apoptotic proteins in determining cell fate

Elizabeth Vafiadaki, Vasiliki Papalouka, Demetrios A. Arvanitis, Evangelia G. Kranias, Despina Sanoudou

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Intracellular calcium is a major coordinator of numerous aspects of cellular physiology, including muscle contractility and cell survival. In cardiac muscle, aberrant Ca2+ cycling has been implicated in a range of pathological conditions including cardiomyopathies and heart failure. The sarco(endo)plasmic reticulum Ca2+ transport adenosine triphosphatase (SERCA2a) and its regulator phospholamban (PLN) have a central role in modulating Ca2+ homeostasis and, therefore, cardiac function. Herein, we discuss the mechanisms through which SERCA2a and PLN control cardiomyocyte function in health and disease. Emphasis is placed on our newly identified PLN-binding partner HS-1-associated protein X-1 (HAX-1), which has an anti-apoptotic function and presents with numerous similarities to Bcl-2. Recent evidence indicates that proteins of the Bcl-2 family can influence ER Ca 2+ content, a critical determinant of cellular sensitivity to apoptosis. The discovery of the PLN/HAX-1 interaction therefore unveils an important new link between Ca2+ homeostasis and cell survival, with significant therapeutic potential.

Original languageEnglish
Pages (from-to)687-700
Number of pages14
JournalPflugers Archiv European Journal of Physiology
Volume457
Issue number3
DOIs
Publication statusPublished - 1 Jan 2009
Externally publishedYes

Fingerprint

Apoptosis Regulatory Proteins
Homeostasis
Muscle
Cell Survival
Cells
Reticulum
Proteins
Physiology
Cardiomyopathies
Cardiac Myocytes
Muscle Cells
Adenosine Triphosphatases
Myocardium
Heart Failure
Health
Apoptosis
Calcium
phospholamban
Therapeutics

Keywords

  • Apoptosis
  • Ca regulation
  • Calcium ATPase
  • Cardiac function
  • Mitochondria
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

The role of SERCA2a/PLN complex, Ca2+ homeostasis, and anti-apoptotic proteins in determining cell fate. / Vafiadaki, Elizabeth; Papalouka, Vasiliki; Arvanitis, Demetrios A.; Kranias, Evangelia G.; Sanoudou, Despina.

In: Pflugers Archiv European Journal of Physiology, Vol. 457, No. 3, 01.01.2009, p. 687-700.

Research output: Contribution to journalArticle

Vafiadaki, Elizabeth ; Papalouka, Vasiliki ; Arvanitis, Demetrios A. ; Kranias, Evangelia G. ; Sanoudou, Despina. / The role of SERCA2a/PLN complex, Ca2+ homeostasis, and anti-apoptotic proteins in determining cell fate. In: Pflugers Archiv European Journal of Physiology. 2009 ; Vol. 457, No. 3. pp. 687-700.
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