The role of micrornas in cardiovascular disease

Despina Sanoudou, Dimitris Tousoulis, Dennis V. Cokkinos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MicroRNAs were discovered approximately two decades ago, and have dramatically changed our understanding of physiological and pathological functions since. These small (?22 nucleotides in length) non- coding RNAs, have the ability to silence the expression of various genes either through mRNA degradation or prevention of mRNA translation to proteins. They have been associated with cardiac development, structure and function but also with every aspect of cardiovascular disease. They can be detected in organs but also in the circulation. A constantly expanding number is shown to have diagnostic or prognostic value. Finally, they are already serving as novel therapeutic targets and/or tools, through a broad range of approaches.

Original languageEnglish
Title of host publicationIntroduction to Translational Cardiovascular Research
PublisherSpringer International Publishing
Pages143-165
Number of pages23
ISBN (Print)9783319087986, 9783319087979
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

    Fingerprint

Keywords

  • Cardiovascular Disease
  • Micrornas
  • Mirs
  • Non-Coding Rnas
  • Nucleotides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sanoudou, D., Tousoulis, D., & Cokkinos, D. V. (2015). The role of micrornas in cardiovascular disease. In Introduction to Translational Cardiovascular Research (pp. 143-165). Springer International Publishing. https://doi.org/10.1007/978-3-319-08798-6_9