The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation

Aman Ullah, Peter Jung, Ghanim Ullah, Khaled Machaca

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

During oocyte maturation, the calcium-signaling machinery undergoes a dramatic remodeling resulting in distinctly different calcium-release patterns on all organizational scales from puffs to waves. The dynamics of the Ca 2 + release wave in mature as compared to immature oocytes are defined by a slower propagation speed and longer duration of the high Ca 2 + plateau. In this chapter, we use computational modeling to identify the changes in the signaling machinery, which contribute most significantly to the alterations observed in Ca2 + wave propagation during Xenopus oocyte maturation. In addition to loss of store-operated calcium entry and internalization of plasma membrane pumps, we propose that spatial reorganization of the IP3 receptors in the plane of the ER membrane is a key factor for the observed signaling changes in Ca2 + wave propagation.

Original languageEnglish
Title of host publicationComputational Neuroscience
PublisherElsevier B.V.
Pages83-101
Number of pages19
ISBN (Print)9780123978974
DOIs
Publication statusPublished - 1 Jan 2014

Publication series

NameProgress in Molecular Biology and Translational Science
Volume123
ISSN (Print)1877-1173

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Keywords

  • Calcium channels
  • Calcium signaling
  • Calcium wave
  • Inositol 1,4,5, triphosphate receptors
  • Oocyte maturation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Ullah, A., Jung, P., Ullah, G., & Machaca, K. (2014). The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation. In Computational Neuroscience (pp. 83-101). (Progress in Molecular Biology and Translational Science; Vol. 123). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-397897-400006-1