The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation

Aman Ullah, Peter Jung, Ghanim Ullah, Khaled Machaca

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

During oocyte maturation, the calcium-signaling machinery undergoes a dramatic remodeling resulting in distinctly different calcium-release patterns on all organizational scales from puffs to waves. The dynamics of the Ca 2 + release wave in mature as compared to immature oocytes are defined by a slower propagation speed and longer duration of the high Ca 2 + plateau. In this chapter, we use computational modeling to identify the changes in the signaling machinery, which contribute most significantly to the alterations observed in Ca2 + wave propagation during Xenopus oocyte maturation. In addition to loss of store-operated calcium entry and internalization of plasma membrane pumps, we propose that spatial reorganization of the IP3 receptors in the plane of the ER membrane is a key factor for the observed signaling changes in Ca2 + wave propagation.

Original languageEnglish
Title of host publicationComputational Neuroscience
PublisherElsevier
Pages83-101
Number of pages19
Volume123
ISBN (Print)9780123978974
DOIs
Publication statusPublished - 2014

Publication series

NameProgress in Molecular Biology and Translational Science
Volume123
ISSN (Print)18771173

Fingerprint

Inositol 1,4,5-Trisphosphate Receptors
Oocytes
Cluster Analysis
Calcium
Calcium Signaling
Xenopus
Cell Membrane
Membranes

Keywords

  • Calcium channels
  • Calcium signaling
  • Calcium wave
  • Inositol 1,4,5, triphosphate receptors
  • Oocyte maturation

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Ullah, A., Jung, P., Ullah, G., & Machaca, K. (2014). The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation. In Computational Neuroscience (Vol. 123, pp. 83-101). (Progress in Molecular Biology and Translational Science; Vol. 123). Elsevier. https://doi.org/10.1016/B978-0-12-397897-400006-1

The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation. / Ullah, Aman; Jung, Peter; Ullah, Ghanim; Machaca, Khaled.

Computational Neuroscience. Vol. 123 Elsevier, 2014. p. 83-101 (Progress in Molecular Biology and Translational Science; Vol. 123).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ullah, A, Jung, P, Ullah, G & Machaca, K 2014, The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation. in Computational Neuroscience. vol. 123, Progress in Molecular Biology and Translational Science, vol. 123, Elsevier, pp. 83-101. https://doi.org/10.1016/B978-0-12-397897-400006-1
Ullah A, Jung P, Ullah G, Machaca K. The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation. In Computational Neuroscience. Vol. 123. Elsevier. 2014. p. 83-101. (Progress in Molecular Biology and Translational Science). https://doi.org/10.1016/B978-0-12-397897-400006-1
Ullah, Aman ; Jung, Peter ; Ullah, Ghanim ; Machaca, Khaled. / The role of IP3 Receptor channel clustering in Ca2 + wave propagation during oocyte maturation. Computational Neuroscience. Vol. 123 Elsevier, 2014. pp. 83-101 (Progress in Molecular Biology and Translational Science).
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