The role of intracellular calcium for the development and treatment of neuroblastoma

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

 Neuroblastoma is the second most common paediatric cancer. It develops from undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, the aetiology behind the development of neuroblastoma is still not fully understood. Intracellular calcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processes and, therefore, its concentration is tightly regulated. This review focuses on the role of [Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes the mechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways. Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminated in this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatment in neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosis in cancer cells leading to a more efficient and effective treatment of neuroblastoma.

Original languageEnglish
Pages (from-to)823-848
Number of pages26
JournalCancers
Volume7
Issue number2
DOIs
Publication statusPublished - 22 May 2015

Fingerprint

Neuroblastoma
Calcium
Neoplasms
Apoptosis
Pediatrics
Pharmaceutical Preparations

Keywords

  • ALK
  • Apoptosis
  • Chemotherapeutic treatment
  • Chemotherapy
  • Differentiation
  • Drug resistance
  • FAK
  • Intracellular calcium([Ca<sup>2+</sup>]<inf>i</inf>)
  • Neuroblastoma
  • NGF signalling
  • PI3K/AKT
  • Proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The role of intracellular calcium for the development and treatment of neuroblastoma. / Satheesh, Noothan; Busselberg, Dietrich.

In: Cancers, Vol. 7, No. 2, 22.05.2015, p. 823-848.

Research output: Contribution to journalReview article

@article{4e50632dc37b405ca2ebd8660bf1fcc7,
title = "The role of intracellular calcium for the development and treatment of neuroblastoma",
abstract = " Neuroblastoma is the second most common paediatric cancer. It develops from undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, the aetiology behind the development of neuroblastoma is still not fully understood. Intracellular calcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processes and, therefore, its concentration is tightly regulated. This review focuses on the role of [Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes the mechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways. Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminated in this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatment in neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosis in cancer cells leading to a more efficient and effective treatment of neuroblastoma.",
keywords = "ALK, Apoptosis, Chemotherapeutic treatment, Chemotherapy, Differentiation, Drug resistance, FAK, Intracellular calcium([Ca<sup>2+</sup>]<inf>i</inf>), Neuroblastoma, NGF signalling, PI3K/AKT, Proliferation",
author = "Noothan Satheesh and Dietrich Busselberg",
year = "2015",
month = "5",
day = "22",
doi = "10.3390/cancers7020811",
language = "English",
volume = "7",
pages = "823--848",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - The role of intracellular calcium for the development and treatment of neuroblastoma

AU - Satheesh, Noothan

AU - Busselberg, Dietrich

PY - 2015/5/22

Y1 - 2015/5/22

N2 -  Neuroblastoma is the second most common paediatric cancer. It develops from undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, the aetiology behind the development of neuroblastoma is still not fully understood. Intracellular calcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processes and, therefore, its concentration is tightly regulated. This review focuses on the role of [Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes the mechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways. Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminated in this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatment in neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosis in cancer cells leading to a more efficient and effective treatment of neuroblastoma.

AB -  Neuroblastoma is the second most common paediatric cancer. It develops from undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, the aetiology behind the development of neuroblastoma is still not fully understood. Intracellular calcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processes and, therefore, its concentration is tightly regulated. This review focuses on the role of [Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes the mechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways. Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminated in this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatment in neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosis in cancer cells leading to a more efficient and effective treatment of neuroblastoma.

KW - ALK

KW - Apoptosis

KW - Chemotherapeutic treatment

KW - Chemotherapy

KW - Differentiation

KW - Drug resistance

KW - FAK

KW - Intracellular calcium([Ca<sup>2+</sup>]<inf>i</inf>)

KW - Neuroblastoma

KW - NGF signalling

KW - PI3K/AKT

KW - Proliferation

UR - http://www.scopus.com/inward/record.url?scp=84930946624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930946624&partnerID=8YFLogxK

U2 - 10.3390/cancers7020811

DO - 10.3390/cancers7020811

M3 - Review article

VL - 7

SP - 823

EP - 848

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 2

ER -