The role of intracellular calcium for the development and treatment of neuroblastoma

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11 Citations (Scopus)

Abstract

 Neuroblastoma is the second most common paediatric cancer. It develops from undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, the aetiology behind the development of neuroblastoma is still not fully understood. Intracellular calcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processes and, therefore, its concentration is tightly regulated. This review focuses on the role of [Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes the mechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways. Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminated in this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatment in neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosis in cancer cells leading to a more efficient and effective treatment of neuroblastoma.

Original languageEnglish
Pages (from-to)823-848
Number of pages26
JournalCancers
Volume7
Issue number2
DOIs
Publication statusPublished - 22 May 2015

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Keywords

  • ALK
  • Apoptosis
  • Chemotherapeutic treatment
  • Chemotherapy
  • Differentiation
  • Drug resistance
  • FAK
  • Intracellular calcium([Ca<sup>2+</sup>]<inf>i</inf>)
  • Neuroblastoma
  • NGF signalling
  • PI3K/AKT
  • Proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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