The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Marek Samec, Alena Liskova, Peter Kubatka, Sona Uramova, Pavol Zubor, Samson Mathews Samuel, Anthony Zulli, Martin Pec, Tibor Bielik, Kamil Biringer, Erik Kudela, Jozef Benacka, Mariusz Adamek, Luis Rodrigo, Rachele Ciccocioppo, Taeg Kyu Kwon, Denis Baranenko, Peter Kruzliak, Dietrich Busselberg

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose: Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis. Results: This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research. Conclusions: Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.

Original languageEnglish
Pages (from-to)1665-1679
Number of pages15
JournalJournal of Cancer Research and Clinical Oncology
Volume145
Issue number7
DOIs
Publication statusPublished - 1 Jul 2019

Fingerprint

Phytochemicals
MicroRNAs
Carcinogenesis
Small Untranslated RNA
Regulator Genes
Research
Antineoplastic Agents
Gene Expression
Pharmaceutical Preparations
Genes

Keywords

  • Cancer
  • Carcinogenesis
  • microRNAs
  • Phytochemicals
  • Plant-derived food

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. / Samec, Marek; Liskova, Alena; Kubatka, Peter; Uramova, Sona; Zubor, Pavol; Mathews Samuel, Samson; Zulli, Anthony; Pec, Martin; Bielik, Tibor; Biringer, Kamil; Kudela, Erik; Benacka, Jozef; Adamek, Mariusz; Rodrigo, Luis; Ciccocioppo, Rachele; Kwon, Taeg Kyu; Baranenko, Denis; Kruzliak, Peter; Busselberg, Dietrich.

In: Journal of Cancer Research and Clinical Oncology, Vol. 145, No. 7, 01.07.2019, p. 1665-1679.

Research output: Contribution to journalReview article

Samec, M, Liskova, A, Kubatka, P, Uramova, S, Zubor, P, Mathews Samuel, S, Zulli, A, Pec, M, Bielik, T, Biringer, K, Kudela, E, Benacka, J, Adamek, M, Rodrigo, L, Ciccocioppo, R, Kwon, TK, Baranenko, D, Kruzliak, P & Busselberg, D 2019, 'The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression', Journal of Cancer Research and Clinical Oncology, vol. 145, no. 7, pp. 1665-1679. https://doi.org/10.1007/s00432-019-02940-0
Samec, Marek ; Liskova, Alena ; Kubatka, Peter ; Uramova, Sona ; Zubor, Pavol ; Mathews Samuel, Samson ; Zulli, Anthony ; Pec, Martin ; Bielik, Tibor ; Biringer, Kamil ; Kudela, Erik ; Benacka, Jozef ; Adamek, Mariusz ; Rodrigo, Luis ; Ciccocioppo, Rachele ; Kwon, Taeg Kyu ; Baranenko, Denis ; Kruzliak, Peter ; Busselberg, Dietrich. / The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. In: Journal of Cancer Research and Clinical Oncology. 2019 ; Vol. 145, No. 7. pp. 1665-1679.
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AU - Zubor, Pavol

AU - Mathews Samuel, Samson

AU - Zulli, Anthony

AU - Pec, Martin

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AU - Benacka, Jozef

AU - Adamek, Mariusz

AU - Rodrigo, Luis

AU - Ciccocioppo, Rachele

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AU - Baranenko, Denis

AU - Kruzliak, Peter

AU - Busselberg, Dietrich

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N2 - Purpose: Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis. Results: This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research. Conclusions: Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.

AB - Purpose: Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis. Results: This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research. Conclusions: Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.

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