The role of cholesterol in cancer

Omer F. Kuzu, Mohammad A. Noory, Gavin P. Robertson

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is not one. Furthermore, the Cancer Genome Atlas (TCGA) project using next-generation sequencing has profiled the mutational status and expression levels of all the genes in diverse cancers, including those involved in cholesterol metabolism, providing correlative support for a role of the cholesterol pathway in cancer development. Finally, preclinical studies tend to more consistently support the role of cholesterol in cancer, with several demonstrating that cholesterol homeostasis genes can modulate development. Because of space limitations, this review provides selected examples of the epidemiologic, TCGA, and preclinical data, focusing on alterations in cholesterol homeostasis and its consequent effect on patient survival. In melanoma, this focused analysis demonstrated that enhanced expression of cholesterol synthesis genes was associated with decreased patient survival. Collectively, the studies in melanoma and other cancer types suggested a potential role of disrupted cholesterol homeostasis in cancer development but additional studies are needed to link populationbased epidemiological data, the TCGA database results, and preclinical mechanistic evidence to concretely resolve this controversy.

Original languageEnglish
Pages (from-to)2063-2070
Number of pages8
JournalCancer Research
Volume76
Issue number8
DOIs
Publication statusPublished - 15 Apr 2016
Externally publishedYes

Fingerprint

Cholesterol
Neoplasms
Atlases
Homeostasis
Genome
Melanoma
Genes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Survival
Epidemiologic Studies
Databases
Serum

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The role of cholesterol in cancer. / Kuzu, Omer F.; Noory, Mohammad A.; Robertson, Gavin P.

In: Cancer Research, Vol. 76, No. 8, 15.04.2016, p. 2063-2070.

Research output: Contribution to journalReview article

Kuzu, OF, Noory, MA & Robertson, GP 2016, 'The role of cholesterol in cancer', Cancer Research, vol. 76, no. 8, pp. 2063-2070. https://doi.org/10.1158/0008-5472.CAN-15-2613
Kuzu, Omer F. ; Noory, Mohammad A. ; Robertson, Gavin P. / The role of cholesterol in cancer. In: Cancer Research. 2016 ; Vol. 76, No. 8. pp. 2063-2070.
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