The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities

Iman A. Mohamed, Navaneethakrishnan Krishnamoorthy, Gheyath K. Nasrallah, Sahar Da'as

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Hypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 is amongst the various sarcomeric genes that are associated with HCM. These mutations produce mutated mRNAs and truncated cMyBP-C proteins. In this review, we will discuss the implications and molecular mechanisms involved in MYBPC3 different mutations. Further, we will highlight the novel targets that can be developed into potential therapeutics for the treatment of HMC. J. Cell. Physiol. 232: 1650–1659, 2017.

Original languageEnglish
Pages (from-to)1650-1659
Number of pages10
JournalJournal of Cellular Physiology
Volume232
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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