The role of cancer stem cells in the modulation of anti-tumor immune responses

Cristina Maccalli, Kakil Ibrahim Rasul, Mamoun Elawad, Soldano Ferrone

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Tumor lesions comprise multiple subpopulations of cells including those endowed with “stemness” properties. The latter cells are responsible of tumor initiation, metastasis formation, resistance to conventional therapies and disease recurrence. These relatively rare cells denominated cancer stem cells (CSCs) or cancer initiating cells (CICs) are defined based on self-renewing, multipotency and tumorigenicity. These cells through their immunomodulating features can evade from immunesurveillance, persisting in the form of quiescence and dormancy. They can drive the neoplastic growth and recurrence, even after long latency. Moreover, CSCs/CICs due to their ability to modulate and shape immune responses can represent the component of a tumor causing immunotherapy resistance in cancer patients. In this review a general overview of immunological properties of CSCs/CICs is provided, with a special focus on the mechanisms of modulation of T cell mediated responses. The need to further dissect the mechanisms regulating the immunological profile of CSCs/CICs and their interactions with immune cells and tumor microenvironment is discussed. An improved characterization of the immunological properties of CSCs/CICs will contribute to the rationale design of immunotherapeutic interventions which target these cells and may lead to the eradication of malignant diseases.

Original languageEnglish
JournalSeminars in Cancer Biology
DOIs
Publication statusAccepted/In press - 1 Jan 2018

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Neoplastic Stem Cells
Neoplasms
Disease Eradication
Cellular Microenvironment
Recurrence
Tumor Microenvironment
Cell Communication
Immunotherapy
Neoplasm Metastasis
T-Lymphocytes

Keywords

  • Cancer stem cells
  • Immune escape mechanisms
  • Immune-based interventions
  • Immunological profiling
  • Tumor dormancy

ASJC Scopus subject areas

  • Cancer Research

Cite this

The role of cancer stem cells in the modulation of anti-tumor immune responses. / Maccalli, Cristina; Rasul, Kakil Ibrahim; Elawad, Mamoun; Ferrone, Soldano.

In: Seminars in Cancer Biology, 01.01.2018.

Research output: Contribution to journalArticle

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