The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension

P. G. Fernandez, W. Snedden, H. Idikio, D. Fernandez, B. K. Kim, Christopher Triggle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The precise mechanisms of hypertensive left ventricular hypertrophy and reversal with antihypertensive drugs are unclear and complex. Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) were used to assess the control of hypertension, and reversal of left ventricular hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl). or a low (0.4% NaCl) salt diet. Systolic blood pressure (SBP). diastolic blood pressure (DBP). heart rate (HR), left ventricular weight/body weight (LVwt/Bwt) ratio were determined. Both drugs were effective in reducing blood pressure and left ventricular mass in DS rats placed on a high salt diet. For DR rats under the same conditions, only MK421 induced significant lowering of blood pressure. Neither drug caused significant change in ventricular mass. Both DS and DR rats on a low salt diet underwent significant blood pressure reduction with MK421 but not HTZ. Significant regression of the left ventricle was observed only in DS rats treated with MK421. Regression was not observed in DR rats even though MK421 reduced blood pressure to distinctly hypotensive levels. The dissociation of left ventricular mass and blood pressure control observed with both MK42I and HTZ suggests that pressure after load is not the only factor involved in the pathophysiology of hypertensive cardiac hypertrophy. The mechanisms of anti-hypertensive drug action and salt intake both appear to play a significant if unexplained role.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume44
Issue number8
DOIs
Publication statusPublished - 1984
Externally publishedYes

Fingerprint

Blood pressure
Left Ventricular Hypertrophy
Enalapril
Inbred Dahl Rats
Rats
Blood Pressure
Hypertension
Hydrochlorothiazide
Nutrition
Salts
Antihypertensive Agents
Pressure control
Diet
Sodium-Restricted Diet
Pharmaceutical Preparations
Cardiomegaly
Ventricular Pressure
Heart Ventricles
Heart Rate
Body Weight

Keywords

  • ACE inhibitor
  • Dahl rat
  • Dietary salt
  • Diuretic
  • Enalapril maleate
  • Hydrochlorothiazide

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension. / Fernandez, P. G.; Snedden, W.; Idikio, H.; Fernandez, D.; Kim, B. K.; Triggle, Christopher.

In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 44, No. 8, 1984, p. 711-716.

Research output: Contribution to journalArticle

@article{6a817aed4fa843dc9dec22167727408c,
title = "The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension",
abstract = "The precise mechanisms of hypertensive left ventricular hypertrophy and reversal with antihypertensive drugs are unclear and complex. Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) were used to assess the control of hypertension, and reversal of left ventricular hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8{\%} NaCl). or a low (0.4{\%} NaCl) salt diet. Systolic blood pressure (SBP). diastolic blood pressure (DBP). heart rate (HR), left ventricular weight/body weight (LVwt/Bwt) ratio were determined. Both drugs were effective in reducing blood pressure and left ventricular mass in DS rats placed on a high salt diet. For DR rats under the same conditions, only MK421 induced significant lowering of blood pressure. Neither drug caused significant change in ventricular mass. Both DS and DR rats on a low salt diet underwent significant blood pressure reduction with MK421 but not HTZ. Significant regression of the left ventricle was observed only in DS rats treated with MK421. Regression was not observed in DR rats even though MK421 reduced blood pressure to distinctly hypotensive levels. The dissociation of left ventricular mass and blood pressure control observed with both MK42I and HTZ suggests that pressure after load is not the only factor involved in the pathophysiology of hypertensive cardiac hypertrophy. The mechanisms of anti-hypertensive drug action and salt intake both appear to play a significant if unexplained role.",
keywords = "ACE inhibitor, Dahl rat, Dietary salt, Diuretic, Enalapril maleate, Hydrochlorothiazide",
author = "Fernandez, {P. G.} and W. Snedden and H. Idikio and D. Fernandez and Kim, {B. K.} and Christopher Triggle",
year = "1984",
doi = "10.3109/00365518409083634",
language = "English",
volume = "44",
pages = "711--716",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
issn = "0036-5513",
publisher = "Informa Healthcare",
number = "8",

}

TY - JOUR

T1 - The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension

AU - Fernandez, P. G.

AU - Snedden, W.

AU - Idikio, H.

AU - Fernandez, D.

AU - Kim, B. K.

AU - Triggle, Christopher

PY - 1984

Y1 - 1984

N2 - The precise mechanisms of hypertensive left ventricular hypertrophy and reversal with antihypertensive drugs are unclear and complex. Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) were used to assess the control of hypertension, and reversal of left ventricular hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl). or a low (0.4% NaCl) salt diet. Systolic blood pressure (SBP). diastolic blood pressure (DBP). heart rate (HR), left ventricular weight/body weight (LVwt/Bwt) ratio were determined. Both drugs were effective in reducing blood pressure and left ventricular mass in DS rats placed on a high salt diet. For DR rats under the same conditions, only MK421 induced significant lowering of blood pressure. Neither drug caused significant change in ventricular mass. Both DS and DR rats on a low salt diet underwent significant blood pressure reduction with MK421 but not HTZ. Significant regression of the left ventricle was observed only in DS rats treated with MK421. Regression was not observed in DR rats even though MK421 reduced blood pressure to distinctly hypotensive levels. The dissociation of left ventricular mass and blood pressure control observed with both MK42I and HTZ suggests that pressure after load is not the only factor involved in the pathophysiology of hypertensive cardiac hypertrophy. The mechanisms of anti-hypertensive drug action and salt intake both appear to play a significant if unexplained role.

AB - The precise mechanisms of hypertensive left ventricular hypertrophy and reversal with antihypertensive drugs are unclear and complex. Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) were used to assess the control of hypertension, and reversal of left ventricular hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl). or a low (0.4% NaCl) salt diet. Systolic blood pressure (SBP). diastolic blood pressure (DBP). heart rate (HR), left ventricular weight/body weight (LVwt/Bwt) ratio were determined. Both drugs were effective in reducing blood pressure and left ventricular mass in DS rats placed on a high salt diet. For DR rats under the same conditions, only MK421 induced significant lowering of blood pressure. Neither drug caused significant change in ventricular mass. Both DS and DR rats on a low salt diet underwent significant blood pressure reduction with MK421 but not HTZ. Significant regression of the left ventricle was observed only in DS rats treated with MK421. Regression was not observed in DR rats even though MK421 reduced blood pressure to distinctly hypotensive levels. The dissociation of left ventricular mass and blood pressure control observed with both MK42I and HTZ suggests that pressure after load is not the only factor involved in the pathophysiology of hypertensive cardiac hypertrophy. The mechanisms of anti-hypertensive drug action and salt intake both appear to play a significant if unexplained role.

KW - ACE inhibitor

KW - Dahl rat

KW - Dietary salt

KW - Diuretic

KW - Enalapril maleate

KW - Hydrochlorothiazide

UR - http://www.scopus.com/inward/record.url?scp=0021677908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021677908&partnerID=8YFLogxK

U2 - 10.3109/00365518409083634

DO - 10.3109/00365518409083634

M3 - Article

VL - 44

SP - 711

EP - 716

JO - Scandinavian Journal of Clinical and Laboratory Investigation

JF - Scandinavian Journal of Clinical and Laboratory Investigation

SN - 0036-5513

IS - 8

ER -