The respiratory rhythm in mutant oscillator mice

Dietrich Büsselberg, Anne M. Bischoff, Kristina Becker, Cord Michael Becker, Diethelm Wolfgang Richter

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27 Citations (Scopus)

Abstract

Since glycinergic inhibition is important for respiratory rhythm generation in mature mammals, we tested the hypothesis that the loss of glycine receptors during postnatal development (P17-P23) of homozygous mutant oscillator mice (spdot/spdot) may result in serious impairment of respiratory rhythm. We measured breathing in a plethysmographic recording chamber on conscious oscillator mice and used an in situ perfused brainstem preparation to record phrenic nerve activity, as well as membrane properties of respiratory neurones. The deletion of glycinergic inhibition did not result in failure of respiratory rhythm: homozygous mutant oscillator mice continue to generate a disturbed respiratory rhythm until death. Postsynaptic activity and membrane potential trajectories of respiratory neurones revealed a persistence of GABAergic inhibition and changes in respiratory rhythm and pattern generation.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalNeuroscience Letters
Volume316
Issue number2
DOIs
Publication statusPublished - 18 Dec 2001
Externally publishedYes

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Keywords

  • Breathing
  • Glycine receptors
  • Mutant oscillator mice
  • Respiratory rhythm generation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Büsselberg, D., Bischoff, A. M., Becker, K., Becker, C. M., & Richter, D. W. (2001). The respiratory rhythm in mutant oscillator mice. Neuroscience Letters, 316(2), 99-102. https://doi.org/10.1016/S0304-3940(01)02382-5