The relationship of immune cell signatures to patient survival varies within and between tumor types

Peter S. Linsley, Damien J. Chaussabel, Cate Speake

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Enhancing pre-existing anti-tumor immunity leads to therapeutic benefit for some patients, but why some tumors are more immunogenic than others remains unresolved. We took a unique systems approach to relate patient survival to immune gene expression in >3,500 tumor RNAseq profiles from a dozen tumor types. We found significant links between immune gene expression and patient survival in 8/12 tumor types, with tumors partitioned by gene expression comprising distinct molecular subtypes. T/NK cell genes were most clearly survival-related for melanoma, head and neck, and bladder tumors, whereas myeloid cell genes were most clearly survival-related with kidney and breast tumors. T/NK or myeloid cell gene expression was linked to poor prognosis in bladder and kidney tumors, respectively, suggesting tumor-specific immunosuppressive checkpoints. Our results suggest new biomarkers for existing cancer immunotherapies and identify targets for new immunotherapies.

Original languageEnglish
Article numbere0138726
JournalPLoS One
Volume10
Issue number9
DOIs
Publication statusPublished - 23 Sep 2015
Externally publishedYes

Fingerprint

Tumors
neoplasms
Survival
Neoplasms
Gene expression
Gene Expression
cells
Myeloid Cells
gene expression
Urinary Bladder Neoplasms
Natural Killer Cells
Immunotherapy
immunotherapy
Kidney
kidneys
Genes
Immunosuppressive Agents
Tumor Biomarkers
Systems Analysis
immunosuppressive agents

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The relationship of immune cell signatures to patient survival varies within and between tumor types. / Linsley, Peter S.; Chaussabel, Damien J.; Speake, Cate.

In: PLoS One, Vol. 10, No. 9, e0138726, 23.09.2015.

Research output: Contribution to journalArticle

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