The Qatar Biobank: Background and methods Chronic Disease epidemiology

Hanan Al Kuwari, Asma Al Thani, Ajayeb Al Marri, Abdulla Al Kaabi, Hadi Abderrahim, Nahla Afifi, Fatima Qafoud, Queenie Chan, Ioanna Tzoulaki, Paul Downey, Heather Ward, Neil Murphy, Elio Riboli, Paul Elliott

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Background: The Qatar Biobank aims to collect extensive lifestyle, clinical, and biological information from up to 60,000 men and women Qatari nationals and long-term residents (individuals living in the country for ≥15 years) aged ≥18 years (approximately one-fifth of all Qatari citizens), to follow up these same individuals over the long term to record any subsequent disease, and hence to study the causes and progression of disease, and disease burden, in the Qatari population. Methods: Between the 11th-December-2012 and 20th-February-2014, 1209 participants were recruited into the pilot study of the Qatar Biobank. At recruitment, extensive phenotype information was collected from each participant, including information/measurements of socio-demographic factors, prevalent health conditions, diet, lifestyle, anthropometry, body composition, bone health, cognitive function, grip strength, retinal imaging, total body dual energy X-ray absorptiometry, and measurements of cardiovascular and respiratory function. Blood, urine, and saliva were collected and stored for future research use. A panel of 66 clinical biomarkers was routinely measured on fresh blood samples in all participants. Rates of recruitment are to be progressively increased in the coming period and the recruitment base widened to achieve a cohort of consented individuals broadly representative of the eligible Qatari population. In addition, it is planned to add additional measures in sub-samples of the cohort, including Magnetic Resonance Imaging (MRI) of the brain, heart and abdomen. Results: The mean time for collection of the extensive phenotypic information and biological samples from each participant at the baseline recruitment visit was 179 min. The 1209 pilot study participants (506 men and 703 women) were aged between 28-80 years (median 39 years); 899 (74.4 %) were Qatari nationals and 310 (25.6 %) were long-term residents. Approximately two-thirds of pilot participants were educated to graduate level or above. Conclusions: The pilot has proven that recruitment of volunteers into the Qatar Biobank project with intensive baseline measurements of behavioural, physical, and clinical characteristics is well accepted and logistically feasible. Qatar Biobank will provide a powerful resource to investigate the major determinants of ill-health and well-being in Qatar, providing valuable insights into the current and future public health burden that faces the country.

    Original languageEnglish
    Article number1208
    JournalBMC Public Health
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 3 Dec 2015

    Fingerprint

    Qatar
    Epidemiology
    Chronic Disease
    Life Style
    Health
    Anthropometry
    Photon Absorptiometry
    Hand Strength
    Body Composition
    Saliva
    Abdomen
    Cognition
    Population
    Disease Progression
    Volunteers
    Public Health
    Biomarkers
    Magnetic Resonance Imaging
    Demography
    Urine

    Keywords

    • Biobank
    • Cohort study
    • Obesity
    • Population health
    • Risk factors

    ASJC Scopus subject areas

    • Public Health, Environmental and Occupational Health

    Cite this

    Al Kuwari, H., Al Thani, A., Al Marri, A., Al Kaabi, A., Abderrahim, H., Afifi, N., ... Elliott, P. (2015). The Qatar Biobank: Background and methods Chronic Disease epidemiology. BMC Public Health, 15(1), [1208]. https://doi.org/10.1186/s12889-015-2522-7

    The Qatar Biobank : Background and methods Chronic Disease epidemiology. / Al Kuwari, Hanan; Al Thani, Asma; Al Marri, Ajayeb; Al Kaabi, Abdulla; Abderrahim, Hadi; Afifi, Nahla; Qafoud, Fatima; Chan, Queenie; Tzoulaki, Ioanna; Downey, Paul; Ward, Heather; Murphy, Neil; Riboli, Elio; Elliott, Paul.

    In: BMC Public Health, Vol. 15, No. 1, 1208, 03.12.2015.

    Research output: Contribution to journalArticle

    Al Kuwari, H, Al Thani, A, Al Marri, A, Al Kaabi, A, Abderrahim, H, Afifi, N, Qafoud, F, Chan, Q, Tzoulaki, I, Downey, P, Ward, H, Murphy, N, Riboli, E & Elliott, P 2015, 'The Qatar Biobank: Background and methods Chronic Disease epidemiology', BMC Public Health, vol. 15, no. 1, 1208. https://doi.org/10.1186/s12889-015-2522-7
    Al Kuwari H, Al Thani A, Al Marri A, Al Kaabi A, Abderrahim H, Afifi N et al. The Qatar Biobank: Background and methods Chronic Disease epidemiology. BMC Public Health. 2015 Dec 3;15(1). 1208. https://doi.org/10.1186/s12889-015-2522-7
    Al Kuwari, Hanan ; Al Thani, Asma ; Al Marri, Ajayeb ; Al Kaabi, Abdulla ; Abderrahim, Hadi ; Afifi, Nahla ; Qafoud, Fatima ; Chan, Queenie ; Tzoulaki, Ioanna ; Downey, Paul ; Ward, Heather ; Murphy, Neil ; Riboli, Elio ; Elliott, Paul. / The Qatar Biobank : Background and methods Chronic Disease epidemiology. In: BMC Public Health. 2015 ; Vol. 15, No. 1.
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    AU - Al Kuwari, Hanan

    AU - Al Thani, Asma

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    AU - Al Kaabi, Abdulla

    AU - Abderrahim, Hadi

    AU - Afifi, Nahla

    AU - Qafoud, Fatima

    AU - Chan, Queenie

    AU - Tzoulaki, Ioanna

    AU - Downey, Paul

    AU - Ward, Heather

    AU - Murphy, Neil

    AU - Riboli, Elio

    AU - Elliott, Paul

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    N2 - Background: The Qatar Biobank aims to collect extensive lifestyle, clinical, and biological information from up to 60,000 men and women Qatari nationals and long-term residents (individuals living in the country for ≥15 years) aged ≥18 years (approximately one-fifth of all Qatari citizens), to follow up these same individuals over the long term to record any subsequent disease, and hence to study the causes and progression of disease, and disease burden, in the Qatari population. Methods: Between the 11th-December-2012 and 20th-February-2014, 1209 participants were recruited into the pilot study of the Qatar Biobank. At recruitment, extensive phenotype information was collected from each participant, including information/measurements of socio-demographic factors, prevalent health conditions, diet, lifestyle, anthropometry, body composition, bone health, cognitive function, grip strength, retinal imaging, total body dual energy X-ray absorptiometry, and measurements of cardiovascular and respiratory function. Blood, urine, and saliva were collected and stored for future research use. A panel of 66 clinical biomarkers was routinely measured on fresh blood samples in all participants. Rates of recruitment are to be progressively increased in the coming period and the recruitment base widened to achieve a cohort of consented individuals broadly representative of the eligible Qatari population. In addition, it is planned to add additional measures in sub-samples of the cohort, including Magnetic Resonance Imaging (MRI) of the brain, heart and abdomen. Results: The mean time for collection of the extensive phenotypic information and biological samples from each participant at the baseline recruitment visit was 179 min. The 1209 pilot study participants (506 men and 703 women) were aged between 28-80 years (median 39 years); 899 (74.4 %) were Qatari nationals and 310 (25.6 %) were long-term residents. Approximately two-thirds of pilot participants were educated to graduate level or above. Conclusions: The pilot has proven that recruitment of volunteers into the Qatar Biobank project with intensive baseline measurements of behavioural, physical, and clinical characteristics is well accepted and logistically feasible. Qatar Biobank will provide a powerful resource to investigate the major determinants of ill-health and well-being in Qatar, providing valuable insights into the current and future public health burden that faces the country.

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    KW - Biobank

    KW - Cohort study

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    KW - Population health

    KW - Risk factors

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