The protective role of curcumin in myocardial ischemia-reperfusion injury

Amin Mokhtari-Zaer, Narges Marefati, Stephen Atkin, Alexandra E. Butler, Amirhossein Sahebkar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is a well-known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia-reperfusion (I-R). Currently, no efficacious treatment of protecting the heart against myocardial I-R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial-reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I-R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I-R injury. This paper presents a brief review of the pathophysiology of myocardial I-R injury and the mechanisms of action of curcumin in reducing myocardial I-R injury.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Myocardial Reperfusion Injury
Curcumin
Reperfusion Injury
Myocardial Ischemia
Coronary Artery Disease
Phytochemicals
Myocardial Reperfusion
Reperfusion
Ischemia
Morbidity
Mortality
Wounds and Injuries

Keywords

  • Coronary artery disease
  • Curcumin
  • Herbal medicine
  • Myocardial ischemia-reperfusion injury

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

The protective role of curcumin in myocardial ischemia-reperfusion injury. / Mokhtari-Zaer, Amin; Marefati, Narges; Atkin, Stephen; Butler, Alexandra E.; Sahebkar, Amirhossein.

In: Journal of Cellular Physiology, 01.01.2018.

Research output: Contribution to journalArticle

Mokhtari-Zaer, Amin ; Marefati, Narges ; Atkin, Stephen ; Butler, Alexandra E. ; Sahebkar, Amirhossein. / The protective role of curcumin in myocardial ischemia-reperfusion injury. In: Journal of Cellular Physiology. 2018.
@article{bd7c600666ce4fa9858a0a280c39188c,
title = "The protective role of curcumin in myocardial ischemia-reperfusion injury",
abstract = "Coronary artery disease (CAD) is a well-known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia-reperfusion (I-R). Currently, no efficacious treatment of protecting the heart against myocardial I-R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial-reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I-R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I-R injury. This paper presents a brief review of the pathophysiology of myocardial I-R injury and the mechanisms of action of curcumin in reducing myocardial I-R injury.",
keywords = "Coronary artery disease, Curcumin, Herbal medicine, Myocardial ischemia-reperfusion injury",
author = "Amin Mokhtari-Zaer and Narges Marefati and Stephen Atkin and Butler, {Alexandra E.} and Amirhossein Sahebkar",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/jcp.26848",
language = "English",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - The protective role of curcumin in myocardial ischemia-reperfusion injury

AU - Mokhtari-Zaer, Amin

AU - Marefati, Narges

AU - Atkin, Stephen

AU - Butler, Alexandra E.

AU - Sahebkar, Amirhossein

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Coronary artery disease (CAD) is a well-known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia-reperfusion (I-R). Currently, no efficacious treatment of protecting the heart against myocardial I-R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial-reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I-R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I-R injury. This paper presents a brief review of the pathophysiology of myocardial I-R injury and the mechanisms of action of curcumin in reducing myocardial I-R injury.

AB - Coronary artery disease (CAD) is a well-known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia-reperfusion (I-R). Currently, no efficacious treatment of protecting the heart against myocardial I-R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial-reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I-R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I-R injury. This paper presents a brief review of the pathophysiology of myocardial I-R injury and the mechanisms of action of curcumin in reducing myocardial I-R injury.

KW - Coronary artery disease

KW - Curcumin

KW - Herbal medicine

KW - Myocardial ischemia-reperfusion injury

UR - http://www.scopus.com/inward/record.url?scp=85050597049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050597049&partnerID=8YFLogxK

U2 - 10.1002/jcp.26848

DO - 10.1002/jcp.26848

M3 - Article

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

ER -