The possible role of chromosome X variability in hypertensive familiarity

M. Ciccarelli, R. Finelli, N. Rivera, G. Santulli, R. Izzo, N. De Luca, F. Rozza, Michele Ceccarelli, S. Pagnotta, F. Uliano, R. Tremigliozzi, G. Condorelli, V. Trimarco, G. Iaccarino

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Abstract

Familiarity participates in the pathogenesis of hypertension, although only recently, whole genome studies have proposed regions of the human genome possibly involved in the transmission of the hypertensive phenotype. Although studies have mainly focused on autosome, hitherto the influence of sex on familial transmission of hypertension has not been considered. We analysed the database of the Campania Salute Network of Hypertension center of the Federico II University Hospital of Naples (Italy), using dichotomous variables for paternal and maternal familiarity and gender (male and female) of 12 504 hypertensive patients (6868 males and 5636 females) and 6352 controls (3484 males and 2868 females), totaling 18 856 subjects. In the hypertensive group, familiarity was present in 75% of cases with odds of 3.77 and in only 26% of the normotensives with odds of 0.94. The odds ratio (OR) indicated that familiarity increases the risk of developing hypertension by 2.91 (95% confidence interval (CI)=2.67-3.17, P<0.001) times. Additionally, maternal familiarity was 37% (OR=3.01, 95% CI=2.66-3.41, P<0.001), paternal familiarity was 21% (OR=2.31, 95% CI=2.01-2.68, P<0.001) and the double familiarity was 17% (OR=3.45, 95% CI=2.87-4.01, P<0.001), thus suggesting a plausible association between maternal familiarity and development of hypertension; this finding was observed both in male and in female patients, although the phenomenon was larger in males. Given the dominance of maternal transmission in males, by genome-wide analysis of the X chromosome, we found two regions that were differently distributed in male hypertensives with maternal hypertension. Our data highlight the importance of genetic variants in the X chromosome to the maternal transmission of the hypertensive phenotype.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalJournal of Human Hypertension
Volume31
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

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X Chromosome
Mothers
Hypertension
Odds Ratio
Confidence Intervals
Genome
Phenotype
Recognition (Psychology)
Human Genome
Italy
Databases

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ciccarelli, M., Finelli, R., Rivera, N., Santulli, G., Izzo, R., De Luca, N., ... Iaccarino, G. (2017). The possible role of chromosome X variability in hypertensive familiarity. Journal of Human Hypertension, 31(1), 37-42. https://doi.org/10.1038/jhh.2016.9

The possible role of chromosome X variability in hypertensive familiarity. / Ciccarelli, M.; Finelli, R.; Rivera, N.; Santulli, G.; Izzo, R.; De Luca, N.; Rozza, F.; Ceccarelli, Michele; Pagnotta, S.; Uliano, F.; Tremigliozzi, R.; Condorelli, G.; Trimarco, V.; Iaccarino, G.

In: Journal of Human Hypertension, Vol. 31, No. 1, 01.01.2017, p. 37-42.

Research output: Contribution to journalArticle

Ciccarelli, M, Finelli, R, Rivera, N, Santulli, G, Izzo, R, De Luca, N, Rozza, F, Ceccarelli, M, Pagnotta, S, Uliano, F, Tremigliozzi, R, Condorelli, G, Trimarco, V & Iaccarino, G 2017, 'The possible role of chromosome X variability in hypertensive familiarity', Journal of Human Hypertension, vol. 31, no. 1, pp. 37-42. https://doi.org/10.1038/jhh.2016.9
Ciccarelli M, Finelli R, Rivera N, Santulli G, Izzo R, De Luca N et al. The possible role of chromosome X variability in hypertensive familiarity. Journal of Human Hypertension. 2017 Jan 1;31(1):37-42. https://doi.org/10.1038/jhh.2016.9
Ciccarelli, M. ; Finelli, R. ; Rivera, N. ; Santulli, G. ; Izzo, R. ; De Luca, N. ; Rozza, F. ; Ceccarelli, Michele ; Pagnotta, S. ; Uliano, F. ; Tremigliozzi, R. ; Condorelli, G. ; Trimarco, V. ; Iaccarino, G. / The possible role of chromosome X variability in hypertensive familiarity. In: Journal of Human Hypertension. 2017 ; Vol. 31, No. 1. pp. 37-42.
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abstract = "Familiarity participates in the pathogenesis of hypertension, although only recently, whole genome studies have proposed regions of the human genome possibly involved in the transmission of the hypertensive phenotype. Although studies have mainly focused on autosome, hitherto the influence of sex on familial transmission of hypertension has not been considered. We analysed the database of the Campania Salute Network of Hypertension center of the Federico II University Hospital of Naples (Italy), using dichotomous variables for paternal and maternal familiarity and gender (male and female) of 12 504 hypertensive patients (6868 males and 5636 females) and 6352 controls (3484 males and 2868 females), totaling 18 856 subjects. In the hypertensive group, familiarity was present in 75{\%} of cases with odds of 3.77 and in only 26{\%} of the normotensives with odds of 0.94. The odds ratio (OR) indicated that familiarity increases the risk of developing hypertension by 2.91 (95{\%} confidence interval (CI)=2.67-3.17, P<0.001) times. Additionally, maternal familiarity was 37{\%} (OR=3.01, 95{\%} CI=2.66-3.41, P<0.001), paternal familiarity was 21{\%} (OR=2.31, 95{\%} CI=2.01-2.68, P<0.001) and the double familiarity was 17{\%} (OR=3.45, 95{\%} CI=2.87-4.01, P<0.001), thus suggesting a plausible association between maternal familiarity and development of hypertension; this finding was observed both in male and in female patients, although the phenomenon was larger in males. Given the dominance of maternal transmission in males, by genome-wide analysis of the X chromosome, we found two regions that were differently distributed in male hypertensives with maternal hypertension. Our data highlight the importance of genetic variants in the X chromosome to the maternal transmission of the hypertensive phenotype.",
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