The pathology of human diabetic neuropathy

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60 Citations (Scopus)

Abstract

Quantitative morphological data are presented from a series of studies assessing both nerve fiber and capillary pathology in 30 diabetic patients with varying stages and symptoms of neuropathy. There is a significant relationship between clinical measures of neuropathic severity and myelinated fiber loss. However, unmyelinated fibers continue to regenerate even in patients with established neuropathy. Microvascular abnormalities, particularly basement membrane thickening and endothelial cell hyperplasia, are an early feature of diabetic microangiopathy and relate to neuropathic severity. There are no neurophysiological or morphological differences between patients with type 1 and type 2 diabetes nor between diabetic patients with and without painful neuropathy.

Original languageEnglish
JournalDiabetes
Volume46
Issue numberSUPPL. 2
Publication statusPublished - Sep 1997
Externally publishedYes

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Diabetic Neuropathies
Pathology
Diabetic Angiopathies
Type 1 Diabetes Mellitus
Nerve Fibers
Basement Membrane
Type 2 Diabetes Mellitus
Hyperplasia
Endothelial Cells

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The pathology of human diabetic neuropathy. / Malik, Rayaz.

In: Diabetes, Vol. 46, No. SUPPL. 2, 09.1997.

Research output: Contribution to journalArticle

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